O-methylneferine

Base Information

Chemical Name:O-methylneferine
CAS No.:2385-62-8
Molecular Formula:C₃₉H₄₆N₂O₆
Molecular Weight:638.804
Hs Code.:

Synonyms:O-methylneferine

Suppliers and Price of O-methylneferine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O-methylneferine

Chemical Property:

Purity/Quality:

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Technology Process of O-methylneferine

There total 19 articles about O-methylneferine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 19879-50-6
(R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol

: 70400-29-2,72527-27-6
(R)-1-(3-bromo-4-methoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 2385-62-8
O-methylneferine

Guidance literature:: With pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate; for 20h; Inert atmosphere; Reflux;
DOI:10.3987/COM-18-S(T)64

Reference yield:

: 116185-11-6
benzyl 3-[4-(benzyloxy)-3-methoxyphenyl]propanoate

: 2385-62-8
O-methylneferine

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / ethanol; water / 1 h / 20 °C

2: diphenyl phosphoryl azide; triethylamine / toluene / 0.5 h / 0 °C / Reflux

3: toluene / 1 h / 20 °C / Cooling with ice

4: trifluoroacetic acid / dichloromethane / 16 h / -20 °C

5: sodium butanolate / butan-1-ol / 1 h / Reflux

6: sodium tetrahydroborate / methanol; water / 1 h / 20 °C

7: acetic acid; palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C

8: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Inert atmosphere; Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; triethylamine; sodium butanolate; trifluoroacetic acid; sodium hydroxide; In methanol; ethanol; dichloromethane; water; toluene; butan-1-ol; 2: |Curtius Rearrangement / 4: |Pictet-Spengler Synthesis / 8: |Ullmann Condensation;
DOI:10.3987/COM-18-S(T)64

Reference yield:

: 30034-49-2
β-(4-benzyloxy-3-methoxyphenyl)propionic acid

: 2385-62-8
O-methylneferine

Guidance literature:: Multi-step reaction with 7 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 0.5 h / 0 °C / Reflux

2: toluene / 1 h / 20 °C / Cooling with ice

3: trifluoroacetic acid / dichloromethane / 16 h / -20 °C

4: sodium butanolate / butan-1-ol / 1 h / Reflux

5: sodium tetrahydroborate / methanol; water / 1 h / 20 °C

6: acetic acid; palladium on activated charcoal; hydrogen / methanol / 16 h / 20 °C

7: pyridine; copper(I) bromide dimethylsulfide complex; caesium carbonate / 20 h / Inert atmosphere; Reflux

With pyridine; sodium tetrahydroborate; copper(I) bromide dimethylsulfide complex; diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; triethylamine; sodium butanolate; trifluoroacetic acid; In methanol; dichloromethane; water; toluene; butan-1-ol; 1: |Curtius Rearrangement / 3: |Pictet-Spengler Synthesis / 7: |Ullmann Condensation;
DOI:10.3987/COM-18-S(T)64