19879-50-6

Basic information

• Product Name: (1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol
• CAS NO: 19879-50-6
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.3908
• Mol File: 19879-50-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 462°C at 760 mmHg
• Flash Point: 233.2°C
• Density: 1.151g/cm³
• Vapor Pressure: 3.7E-09mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: (1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol(19879-50-6)
• EPA Substance Registry System: (1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ol(19879-50-6)

Safety Data

• Hazardous Substances Data: 19879-50-6(Hazardous Substances Data)

Upstream product

• 481-49-2 cepharanthine 
• 1135-23-5 3-(4-hydroxy-3-methoxyphenyl)propionic acid 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 101565-19-9 (E/Z)-1-methoxy-4-(2-methoxyvinyl)benzene 
• 22231-61-4 2-[4-(benzyloxy)-3-methoxyphenyl]ethylamine 
• 30034-49-2 β-(4-benzyloxy-3-methoxyphenyl)propionic acid 
• 116185-11-6 benzyl 3-[4-(benzyloxy)-3-methoxyphenyl]propanoate 
• 15357-95-6 7-(benzyloxy)-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 1263209-98-8 7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 21858-17-3 (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1438250-58-8 (1R)-7-(benzyloxy)-2-[(4S)-4,5-dihydro-4-(1-methylethyl)-2-oxazolyl]-6-methoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1438250-78-2 (S)-1-(4-(benzyloxy)-3-((R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yloxy)benzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 2292-16-2 1'-epi-neferine 
• 2385-62-8 O-methylneferine 

Relevant articles and documents

Asymmetric synthesis of O-methylneferine

Diastereoselective Pictet-Spengler reaction of 2-arylethylamine bearing an N-(R)-1-(1-naphthyl)ethylcarbamoyl group with arylacetaldehyde gave 1-benzyltetrahydroisoquinoline in good yield with moderate diastereoselectivity. The reaction was applied to asymmetric synthesis of O-methyl derivative of neferine, an alkaloid of the lotus embryo, Nelumbo nucifera Gaertner.