exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Base Information

Chemical Name:exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one
CAS No.:461412-44-2
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Suppliers and Price of exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

There total 6 articles about exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 461412-42-0
exo-(5S,6R)-3-((R)-methoxyphenylacetyl)-6-phenyl-6-[(triethylsilyl)oxy]-1,3-diazabicyclo[3.3.0]octan-2-one

: 461412-44-2
exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1002/1521-3765(20020603)8:11<2464::AID-CHEM2464>3.0.CO;2-S

Reference yield:

: 34713-98-9
(R)-(-)-α-methoxyphenylacetyl chloride

: 461412-44-2
exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LHMDS / tetrahydrofuran / 0.25 h / -78 °C

1.2: 39 percent / tetrahydrofuran / 2 h / 20 °C

2.1: 89 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

With tetrabutyl ammonium fluoride; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1002/1521-3765(20020603)8:11<2464::AID-CHEM2464>3.0.CO;2-S

Reference yield:

: 461412-31-7
N-acetyl-N'-(3-oxo-3-phenylpropyl)imidazolidin-2-one

: 461412-44-2
exo-(5S,6R)-6-hydroxy-3-((R)-methoxyphenylacetyl)-6-phenyl-1,3-diazabicyclo[3.3.0]octan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 40 percent / toluene / 3 h / 35 °C / Irradiation

2.1: 2,6-lutidine / CH₂Cl₂ / 18 h / 0 - 20 °C

3.1: 363 mg / K₂CO₃ / methanol / 3 h / 20 °C

4.1: LHMDS / tetrahydrofuran / 0.25 h / -78 °C

4.2: 39 percent / tetrahydrofuran / 2 h / 20 °C

5.1: 89 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; toluene; 1.1: Norrish-Yang cyclization;
DOI:10.1002/1521-3765(20020603)8:11<2464::AID-CHEM2464>3.0.CO;2-S