34713-98-9Relevant academic research and scientific papers
Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 17. The Spiro Mode. Efficient and Highly Selective Synthesis of Azapropellanes
Denmark, Scott E.,Middleton, Donald S.
, p. 1604 - 1618 (1998)
A new variant of the tandem inter [4 + 2]/intra [3 + 2] nitroalkene cycloaddition has been developed. Intermolecular [4 + 2] cycloaddition of a 2-nitroalkene (bearing an unsaturated ester moiety, the dipolarophile) with a vinyl ether produces a cyclic nit
Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula
Gross, Harald,McPhail, Kerry L.,Goeger, Douglas E.,Valeriote, Frederick A.,Gerwick, William H.
, p. 1729 - 1735 (2010)
Two epimers of malyngamide C, 8-O-acetyl-8-epi-malyngamide C (1) and 8-epi-malyngamide C (3) have been isolated along with known compounds 6-O-acetylmalyngamide F (5), H (6), J (7) K (8), and characterized from a Grenada field collection of the marine cya
Forazoline A: Marine-Derived Polyketide with Antifungal in Vivo Efficacy
Wyche, Thomas P.,Piotrowski, Jeff S.,Hou, Yanpeng,Braun, Doug,Deshpande, Raamesh,McIlwain, Sean,Ong, Irene M.,Myers, Chad L.,Guzei, Ilia A.,Westler, William M.,Andes, David R.,Bugni, Tim S.
, p. 11583 - 11586 (2014)
Forazoline A, a novel antifungal polyketide with in vivo efficacy against Candida albicans, was discovered using LCMS-based metabolomics to investigate marine-invertebrate-associated bacteria. Forazoline A had a highly unusual and unprecedented skeleton.
Asymmetric aldol reaction of 2-cyanopropionates catalyzed by a trans-chelating chiral diphosphine-rhodium(I) complex: Highly enantioselective construction of quaternary chiral carbon centers at α-positions of nitriles
Kuwano, Ryoichi,Miyazaki, Hiroshi,Ito, Yoshihiko
, p. 18 - 29 (2000)
The aldol reaction of 2-cyanopropionates with aldehydes proceeded under neutral conditions in the presence of a catalytic amount of the rhodium complex generated in situ from Rh(acac)(CO)2 and triphenylphosphine, to give the corresponding β-hyd
Mutual kinetic resolution of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines and 2-alkoxyacyl chlorides
Vakarov, Sergey A.,Gruzdev, Dmitry А.,Sadretdinova, Liliya Sh.,Kodess, Mikhail I.,Tumashov, Andrey A.,Gorbunov, Evgeny B.,Levit, Galina L.,Krasnov, Victor P.
, p. 437 - 446 (2018)
[Figure not available: see fulltext.] Stereoselective acylation of racemic 3-methyl-3,4-dihydro-2Н-1,4-benzoxazine and its 7,8-difluoro-substituted analog with racemic 2-alkoxyacyl chlorides was stidied. The reactions of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines with 2-methoxyisopentanoyl chloride were found to be more selective (selectivity factor s 31–32) compared to the acylation with other studied propanoyl chlorides (s 18–21). This fact was probably caused by the significant steric hindrance due to the isopropyl substituent in acyl chloride compared to the methyl group in reagents derived from propanoic acid.
Noduliprevenone: A novel heterodimeric chromanone with cancer chemopreventhe potential
Pontius, Alexander,Krick, Anja,Kehraus, Stefan,Foegen, Silke E.,Mueller, Michael,Klimo, Karin,Gerhaeuser, Clarissa,Koenig, Gabriele M.
, p. 9860 - 9863 (2008)
A study was conducted to report a novel heterodimeric chromanone with can chemopreventive potential. It was demonstrate that the aim of chemopreventive strategy can include the inhibition of phase 1 enzymes accompanied with an increased phase II metabolis
An efficient method for the preparation of enantiomerically pure N- acylarylsulfonamides having an asymmetric center at the α-position: Condensation of acid chlorides and arylsulfonamides under solid-liquid two- phase conditions
Ishizuka, Natsuki,Matsumura, Ken-ichi,Hayashi, Kunio,Sakai, Katsunori,Yamamori, Teruo
, p. 784 - 788 (2000)
A convenient synthetic method for the preparation of enantiomerically pure N-acylarylsulfonamides having an asymmetric center at the α-position of the carbonyl group is described. Chiral phenylacetic acids are first converted to the corresponding acid chl
Bicunningines A and B, two new dimeric diterpenes from Cunninghamia Lanceolata
Hou, Xian-Feng,Yao, Sheng,Mandi, Attila,Kurtan, Tibor,Tang, Chun-Ping,Ke, Chang-Qiang,Li, Xi-Qiang,Ye, Yang
, p. 460 - 463 (2012)
Two unprecedented dimeric diterpenoids, with a 2,3-dihydrofuran ring fusing an abietane and a 4,5-seco-abietane diterpene, were isolated from Cunninghamia lanceolata. Their structures were elucidated by spectroscopic measurements, and their absolute confi
C3-Symmetric Tricyclo[2.2.1.02,6]heptane-3,5,7-triol
Kozel, Volodymyr,Daniliuc, Constantin-Gabriel,Kirsch, Peer,Haufe, Günter
, p. 15456 - 15460 (2017)
A straightforward access to a hitherto unknown C3-symmetric tricyclic triol both in racemic and enantiopure forms has been developed. Treatment of 7-tert-butoxynorbornadiene with peroxycarboxylic acids provided mixtures of C1- and C3-symmetric 3,5,7-triacyloxynortricyclenes via transannular π-cyclization and replacement of the tert-butoxy group. By refluxing in formic acid, the C1-symmetric esters were converted to the C3-symmetric formate. Hydrolysis gave diastereoisomeric triols, which were separated by recrystallization. Enantiomer resolution via diastereoisomeric tri(O-methylmandelates) delivered the target triols on a gram scale. The pure enantiomers are useful as core units of dopants for liquid crystals.
Antiproliferative acetogenins from a Uvaria sp. from the madagascar dry forest(1)
Dai, Yumin,Harinantenaina, Liva,Brodie, Peggy J.,Callmander, Martin W.,Randrianaivo, Richard,Rakotonandrasana, Stephan,Rakotobe, Etienne,Rasamison, Vincent E.,Shen, Yongchun,Tendyke, Karen,Suh, Edward M.,Kingston, David G. I.
, p. 479 - 483 (2012)
Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis
