4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

Base Information

Chemical Name:4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide
CAS No.:1161846-71-4
Molecular Formula:C₃₅H₃₆N₆O₃
Molecular Weight:588.709
Hs Code.:

Synonyms:4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

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Chemical Property of 4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

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Technology Process of 4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

There total 7 articles about 4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64614-49-9
4-[(6-chloro-3-pyridinyl)carbonyl]morpholine

: 1161846-73-6
N-[3-(8-aminoimidazo[1,2-a]pyridin-6-yl)-2-methylphenyl]-4-tert-butylbenzamide

: 1161846-71-4
4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

Guidance literature:: With sodium t-butanolate; palladium diacetate; CyJohnPhos; at 200 ℃; for 1.66667h; Microwave irradiation;

Reference yield:

: 38875-53-5
5-bromo-pyridine-2,3-diamine

: 1161846-71-4
4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; isopropyl alcohol / 24 h / Inert atmosphere; Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 0.33 h / 170 °C / Inert atmosphere; Microwave irradiation

3: palladium diacetate; potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / 1.67 h / 200 °C / Inert atmosphere; Microwave irradiation

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; sodium carbonate; sodium t-butanolate; In 1,2-dimethoxyethane; water; isopropyl alcohol; 2: |Suzuki Coupling;
DOI:10.1021/jm500305p

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 1161846-71-4
4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: palladium diacetate; potassium phosphate; 1,1'-bis-(diphenylphosphino)ferrocene; sodium t-butanolate / 1.67 h / 200 °C / Inert atmosphere; Microwave irradiation

With 1,1'-bis-(diphenylphosphino)ferrocene; potassium phosphate; palladium diacetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; In dichloromethane;
DOI:10.1021/jm500305p