(6-Chloropyridin-3-yl)(morpholino)methanone

Base Information

• Chemical Name: (6-Chloropyridin-3-yl)(morpholino)methanone
• CAS No.: 64614-49-9
• Molecular Formula: C10H11 Cl N2 O2
• Molecular Weight: 226.663
• Hs Code.: 2934999090
• European Community (EC) Number: 850-280-0
• DSSTox Substance ID: DTXSID70357654
• Wikidata: Q82137661
• Mol file: 64614-49-9.mol

Synonyms:64614-49-9;(6-Chloropyridin-3-yl)(morpholino)methanone;4-[(6-chloropyridin-3-yl)carbonyl]morpholine;4-[(6-Chloro-3-pyridinyl)carbonyl]morpholine;4-(6-chloropyridine-3-carbonyl)morpholine;(6-chloropyridin-3-yl)(morpholin-4-yl)methanone;(6-chloropyridin-3-yl)-morpholin-4-ylmethanone;Oprea1_611672;SCHEMBL2072292;DTXSID70357654;BCP09371;MFCD03750290;STK503023;AKOS000160515;AM87117;BS-4337;CS-W013017;4-(6-chloro-3-pyridinyl)carbonylmorpholine;FT-0678978;(6-Chloro-3-pyridinyl)-4-morpholinylmethanone;EN300-236459;F19902;(6-chloro-pyridin-3-yl)-morpholin-4-yl-methanone;A834829;J-514207;Z31721382;1-(6-Chloro-pyridin-3-yl)-1-morpholin-4-yl-methanone;F2147-0228;4-[(6-Chloro-3-pyridinyl)carbonyl]morpholine, AldrichCPR;(6-chloro-3-pyridyl)-morpholino-methanone

Chemical Property of (6-Chloropyridin-3-yl)(morpholino)methanone

Chemical Property:

• Vapor Pressure: 5.93E-07mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 410.6°C at 760 mmHg
• Flash Point: 202.1°C
• PSA: 42.43000
• Density: 1.327g/cm³
• LogP: 1.14530
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 226.0509053
• Heavy Atom Count: 15
• Complexity: 232

Purity/Quality:

97% ^*data from raw suppliers

(6-Chloropyridin-3-yl)(morpholino)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)C2=CN=C(C=C2)Cl

Technology Process of (6-Chloropyridin-3-yl)(morpholino)methanone

There total 3 articles about (6-Chloropyridin-3-yl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + 6-Chloronicotinoyl chloride (58757-38-3) → 4-[(6-chloro-3-pyridinyl)carbonyl]morpholine (64614-49-9)

Guidance literature:

DOI:10.1016/j.bmcl.2003.11.032

Reference yield: 88.0%

→ 4-[(6-chloro-3-pyridinyl)carbonyl]morpholine (64614-49-9)

Guidance literature:

Reference yield:

morpholine (110-91-8,99108-56-2) + 6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 4-[(6-chloro-3-pyridinyl)carbonyl]morpholine (64614-49-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

upstream raw materials:

morpholine

6-Chloronicotinoyl chloride

6-Chloro-3-pyridinecarboxylic acid

Downstream raw materials:

6-tert-butyl-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(morpholine-4-carbonyl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-3,4-dihydro-2H-isoquinolin-1-one

C₃₄H₃₄N₆O₅

6-(dimethylamino)-2-(2-(hydroxymethyl)-3-(1-methyl-5-(5-(morpholine-4-carbonyl)pyridin-2-ylamino)-6-oxo-1,6-dihydropyridin-3-yl)phenyl)-3,4-dihydroisoquinolin-1(2H)-one

4-tert-butyl-N-{2-methyl-3-[8-({5-[(morpholin-4-yl)carbonyl]pyridin-2-yl}amino)imidazo[1,2-a]pyridin-6-yl]phenyl}benzamide