5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Base Information

Chemical Name:5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide
CAS No.:1609467-04-0
Molecular Formula:C₂₅H₂₇N₅O₄
Molecular Weight:461.52
Hs Code.:

Synonyms:5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Chemical Property of 5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

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Technology Process of 5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

There total 8 articles about 5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 330792-69-3
2-[(4-phenoxy-phenyl)-methoxy-methylene]-malononitrile

: 1609467-04-0
5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 16 h / 55 °C

2: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

3: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

4: triethylamine / ethanol

5: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; In 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 24587-49-3
(2E)-4-hydroxybut-2-enoic acid

: 1558038-42-8
(R)-5-amino-3-(4-phenoxyphenyl)-1-piperidin-3-yl-1H-pyrazole-4-carboxylic acid amide

: 1609467-04-0
5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1623-95-6
4-phenoxybenzoyl chloride

: 1609467-04-0
5-amino-1-{(3R)-1-[(2E)-4-hydroxybut-2-enoyl]piperidin-3-yl}-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: triethylamine / ethanol / 16 h / 55 °C

3.1: hydrogen; palladium 10% on activated carbon / 2-methyltetrahydrofuran / 16 h / 65 °C

4.1: sodium hydroxide / ethanol / 0.5 h / 150 °C / Sealed tube

5.1: triethylamine / ethanol

6.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; ethanol; N,N-dimethyl-formamide;