1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

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Chemical Name:1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene
CAS No.:624727-35-1
Molecular Formula:C₂₄H₄₂O₅Si
Molecular Weight:438.68
Hs Code.:

Synonyms:1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

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Chemical Property of 1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

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Technology Process of 1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

There total 10 articles about 1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 624727-34-0
(2S,3R,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-7-[(4-methoxybenzyl)oxy]-3-(methoxymethoxy)-2-methylheptyl 4-methylbenzenesulfonate

: 624727-35-1
1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In various solvent(s); for 3h; Heating;
DOI:10.1021/jo035054g

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 624727-35-1
1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / SnCl₂ / CH₂Cl₂ / 1 h / 20 °C

2: H₂; (R)-(+)-BINAP / [RuCl₂(PhH)]2 / dimethylformamide / 20 h / 90 °C / 3000.24 Torr

3: imidazole; DMAP / dimethylformamide / 48 h

4: DIBAH / CH₂Cl₂; hexane / 3.5 h / -78 °C

5: 5.67 g / TiCl₄; (-)-sparteine / CH₂Cl₂ / 1 h / 0 °C

6: 81 percent / (iPr)2NEt; tetrabutylammonium iodide / CH₂Cl₂ / 72 h / 20 °C

7: 77 percent / LiBH₄ / methanol; tetrahydrofuran / 20 °C

8: 98 percent / pyridine / 2 h / 0 °C

9: 84 percent / NaI; DBU / various solvent(s) / 3 h / Heating

With pyridine; 1H-imidazole; dmap; lithium borohydride; hydrogen; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium iodide; tin(ll) chloride; (-)-sparteine; dichloro(benzene)ruthenium(II) dimer; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035054g

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 624727-35-1
1-({[(3R,5R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-(methoxymethoxy)-6-methylhept-6-enyl]oxy}methyl)-4-methoxybenzene

Guidance literature:: Multi-step reaction with 10 steps

1: ClCH₂CO₂H; aq. NaOH; acetic acid / 144 h / 40 °C

2: 80 percent / SnCl₂ / CH₂Cl₂ / 1 h / 20 °C

3: H₂; (R)-(+)-BINAP / [RuCl₂(PhH)]2 / dimethylformamide / 20 h / 90 °C / 3000.24 Torr

4: imidazole; DMAP / dimethylformamide / 48 h

5: DIBAH / CH₂Cl₂; hexane / 3.5 h / -78 °C

6: 5.67 g / TiCl₄; (-)-sparteine / CH₂Cl₂ / 1 h / 0 °C

7: 81 percent / (iPr)2NEt; tetrabutylammonium iodide / CH₂Cl₂ / 72 h / 20 °C

8: 77 percent / LiBH₄ / methanol; tetrahydrofuran / 20 °C

9: 98 percent / pyridine / 2 h / 0 °C

10: 84 percent / NaI; DBU / various solvent(s) / 3 h / Heating

With pyridine; 1H-imidazole; dmap; sodium hydroxide; lithium borohydride; hydrogen; titanium tetrachloride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; chloroacetic acid; sodium iodide; tin(ll) chloride; (-)-sparteine; dichloro(benzene)ruthenium(II) dimer; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035054g