tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Base Information

• Chemical Name: tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate
• CAS No.: 1402743-80-9
• Molecular Formula: C₂₁H₂₁F₃N₂O₅
• Molecular Weight: 438.403

Synonyms:tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property of tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate

There total 3 articles about tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-fluoro-2-nitro-4-trifluoromethyl-benzene (367-86-2) + tert-butyl [(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-carbamate (766556-66-5) → tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-80-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 - 20 ℃;

DOI:10.1002/anie.201203852

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C

With sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1002/anie.201203852

Reference yield:

(1R,2R)-1-aminoindan-2-ol (163061-73-2) → tert-butyl ((1R,2R)-2-(2-nitro-4-(trifluoromethyl)phenoxy)-2,3-dihydro-1H-inden-1-yl)carbamate (1402743-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tetrahydrofuran; water / 0 - 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 - 20 °C

With sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; water;

DOI:10.1002/anie.201203852

upstream raw materials:

1-fluoro-2-nitro-4-trifluoromethyl-benzene

tert-butyl [(1R,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-carbamate

di-tert-butyl dicarbonate

(1R,2R)-1-aminoindan-2-ol

Downstream raw materials:

C₁₉H₂₀F₃N₃O₂

C₄₆H₄₁F₉N₆O₃S

C₂₈H₃₆F₃N₅O₂S

C₄₀H₄₃F₃N₆O₃S

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