(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Base Information

Chemical Name:(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt
CAS No.:1353637-19-0
Molecular Formula:C₆H₁₅N*C₂₅H₂₄FNO₄
Molecular Weight:522.66
Hs Code.:

Synonyms:(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

There total 13 articles about (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1353637-18-9
E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

: 1353637-19-0
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Guidance literature:: E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide; With water; sodium hydroxide; In ethanol; at 20 - 25 ℃; for 16h;

With hydrogenchloride; In water; ethyl acetate; pH=3 - 4;

With diisopropylamine; In ethyl acetate; at 20 - 25 ℃; for 12h;

Reference yield:

: 108-18-9
diisopropylamine

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

: 1353637-19-0
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Guidance literature:: In acetonitrile; at 25 - 35 ℃;

Reference yield:

: 124655-09-0,407577-54-2
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate

: 1353637-19-0
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid diisopropylamine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2.1: water; sodium hydroxide / methanol / 40 °C

2.2: pH 2 - 4

3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C

3.2: 20 - 25 °C

4.1: potassium carbonate / acetonitrile / 70 °C

4.2: 15 h / 0 - 25 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C

6.1: hydrogenchloride; water / acetonitrile / 12 h / 40 °C

7.1: water; sodium hydroxide / ethanol / 16 h / 20 - 25 °C

7.2: pH 3 - 4

7.3: 12 h / 20 - 25 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; acetonitrile;