E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

Base Information

Chemical Name:E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide
CAS No.:1353637-18-9
Molecular Formula:C₂₇H₂₉FN₂O₄
Molecular Weight:464.537
Hs Code.:

Synonyms:E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

There total 10 articles about E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1353637-17-8
E-(6-{2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-[(4R,6S)-2,2-dimethyl-[1,3]dioxan-4-yl])-N-methoxy-N-methyl-acetamide

: 1353637-18-9
E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

Guidance literature:: With hydrogenchloride; water; In acetonitrile; at 40 ℃; for 12h;

Reference yield:

: 124655-09-0,407577-54-2
1,1-dimethylethyl (4R-cis)-6-hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate

: 1353637-18-9
E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 5 °C

2.1: water; sodium hydroxide / methanol / 40 °C

2.2: pH 2 - 4

3.1: 1,1'-carbonyldiimidazole / ethyl acetate / 3 h / 0 - 30 °C

3.2: 20 - 25 °C

4.1: potassium carbonate / acetonitrile / 70 °C

4.2: 15 h / 0 - 25 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C

6.1: hydrogenchloride; water / acetonitrile / 12 h / 40 °C

With hydrogenchloride; water; potassium carbonate; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 154877-92-6
2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-yl)acetic acid

: 1353637-18-9
E-(7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride / acetonitrile / 1 h / 0 - 30 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 0 - 25 °C

2.2: 10 h / 20 - 25 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 10 °C

4.1: potassium carbonate / acetonitrile / 70 °C

4.2: 15 h / 0 - 25 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 - -10 °C

6.1: hydrogenchloride; water / acetonitrile / 12 h / 40 °C

With hydrogenchloride; water; potassium carbonate; ammonium chloride; triethylamine; 1,1'-carbonyldiimidazole; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;