tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

Base Information

Chemical Name:tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane
CAS No.:1393364-39-0
Molecular Formula:C₂₃H₄₀O₃Si₂
Molecular Weight:420.74
Hs Code.:

Synonyms:tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

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Chemical Property of tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

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Technology Process of tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

There total 6 articles about tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1393364-32-3
(3S,4S)-5-(4-methoxybenzyloxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-ol

: 69739-34-0
t-butyldimethylsiyl triflate

: 1393364-39-0
tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;
DOI:10.1039/c2cc34052f

Reference yield:

: 132969-71-2
methyl (2S)-[(4-methoxybenzyl)oxy]-2-methylpropanoate

: 1393364-39-0
tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 2.75 h / -78 °C / Inert atmosphere

2.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

3.1: diethylzinc / toluene / 1 h / Inert atmosphere; Reflux

3.2: 1 h / 20 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; diethylzinc; diisobutylaluminium hydride; Dess-Martin periodane; In hexane; dichloromethane; toluene;
DOI:10.1039/c2cc34052f

Reference yield:

: 136320-64-4
(2R)-3-[(4-methoxybenzyl)oxy]-2-methylpropanol

: 1393364-39-0
tert-butyl(((3S,4S)-5-((4-methoxybenzyl)oxy)-4-methyl-1-(trimethylsilyl)pent-1-yn-3-yl)oxy)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: Dess-Martin periodane / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

2.1: diethylzinc / toluene / 1 h / Inert atmosphere; Reflux

2.2: 1 h / 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 °C / Inert atmosphere

With 2,6-dimethylpyridine; diethylzinc; Dess-Martin periodane; In dichloromethane; toluene;
DOI:10.1039/c2cc34052f