dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)

Base Information

• Chemical Name: dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)
• CAS No.: 905267-23-4
• Molecular Formula: C₂₈H₃₄O₁₀
• Molecular Weight: 530.572
• Mol file: 905267-23-4.mol

Synonyms:dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)

Chemical Property of dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)

There total 4 articles about dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

methyl 5-iodo-2-(2-(2-methoxyethoxy)ethoxy)benzoate (905267-22-3) + acetylene (74-86-2,25067-58-7) → dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate) (905267-23-4)

Guidance literature:

With piperidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 80 ℃; for 0.333333h;

DOI:10.1016/j.tet.2006.04.082

Reference yield:

methyl 2-(2-(2-methoxyethoxy)ethoxy)benzoate (905267-21-2) → dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate) (905267-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / iodine; silver(I) sulfate / methanol / 0.5 h / 20 °C

2: 83 percent / CuI; piperidine / Pd(PPh₃)4 / 0.33 h / 80 °C

With piperidine; copper(l) iodide; iodine; silver sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol;

DOI:10.1016/j.tet.2006.04.082

Reference yield:

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester (50586-80-6,58320-73-3) → dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate) (905267-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / K₂CO₃ / acetonitrile / 7 h / Heating

2: 89 percent / iodine; silver(I) sulfate / methanol / 0.5 h / 20 °C

3: 83 percent / CuI; piperidine / Pd(PPh₃)4 / 0.33 h / 80 °C

With piperidine; copper(l) iodide; iodine; potassium carbonate; silver sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; acetonitrile;

DOI:10.1016/j.tet.2006.04.082

upstream raw materials:

methyl 5-iodo-2-(2-(2-methoxyethoxy)ethoxy)benzoate

acetylene

methyl 2-(2-(2-methoxyethoxy)ethoxy)benzoate

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester

Downstream raw materials:

5-((3-(methoxycarbonyl)-4-(2-(2-methoxyethoxy)ethoxy)phenyl)ethynyl)-2-(2-(2-methoxyethoxy)ethoxy)benzoic acid

5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)