5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)

Base Information

• Chemical Name: 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)
• CAS No.: 905267-24-5
• Molecular Formula: C₂₆H₃₀O₁₀
• Molecular Weight: 502.518
• Mol file: 905267-24-5.mol

Synonyms:5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)

Chemical Property of 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid)

There total 5 articles about 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate) (905267-23-4) → 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) (905267-24-5)

Guidance literature:

With sodium hydroxide; In methanol; water; for 4h; Heating;

DOI:10.1016/j.tet.2006.04.082

Reference yield:

methyl 2-(2-(2-methoxyethoxy)ethoxy)benzoate (905267-21-2) → 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) (905267-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / iodine; silver(I) sulfate / methanol / 0.5 h / 20 °C

2: 83 percent / CuI; piperidine / Pd(PPh₃)4 / 0.33 h / 80 °C

3: 97 percent / sodium hydroxide / methanol; H₂O / 4 h / Heating

With piperidine; sodium hydroxide; copper(l) iodide; iodine; silver sulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water;

DOI:10.1016/j.tet.2006.04.082

Reference yield:

methyl 5-iodo-2-(2-(2-methoxyethoxy)ethoxy)benzoate (905267-22-3) → 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoic acid) (905267-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / CuI; piperidine / Pd(PPh₃)4 / 0.33 h / 80 °C

2: 97 percent / sodium hydroxide / methanol; H₂O / 4 h / Heating

With piperidine; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water;

DOI:10.1016/j.tet.2006.04.082

upstream raw materials:

dimethyl 5,5'-(ethyne-1,2-diyl)bis(2-(2-(2-methoxyethoxy)ethoxy)benzoate)

methyl 2-(2-(2-methoxyethoxy)ethoxy)benzoate

methyl 5-iodo-2-(2-(2-methoxyethoxy)ethoxy)benzoate

toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester