Technology Process of (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-<3,3-(1,4-butanediyl)triazeno>benzamide
There total 8 articles about (S)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-5-<3,3-(1,4-butanediyl)triazeno>benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 18 percent / 10percent HNO3 / H2SO4 / 1 h / 5 °C
2: 95 percent / 2 N NaOH / methanol / 2 h / Heating
3: 97 percent / SOCl2 / toluene; dimethylformamide / 2 h / 75 °C
4: 72 percent / CH2Cl2 / 2 h / 25 °C
5: 78 percent / H2 / 10percent Pd/C / methanol / 1.5 h / Ambient temperature
6: 1.) 1 N HCl, NaNO2 / 1.) acetone, 0 deg C, 15 min, 2.) acetone, H2O, 10 deg C, 1.5 h
With
hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; nitric acid; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; sulfuric acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00118a031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / 2 N NaOH / methanol / 2 h / Heating
2: 97 percent / SOCl2 / toluene; dimethylformamide / 2 h / 75 °C
3: 72 percent / CH2Cl2 / 2 h / 25 °C
4: 78 percent / H2 / 10percent Pd/C / methanol / 1.5 h / Ambient temperature
5: 1.) 1 N HCl, NaNO2 / 1.) acetone, 0 deg C, 15 min, 2.) acetone, H2O, 10 deg C, 1.5 h
With
hydrogenchloride; sodium hydroxide; thionyl chloride; hydrogen; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00118a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / SOCl2 / toluene; dimethylformamide / 2 h / 75 °C
2: 72 percent / CH2Cl2 / 2 h / 25 °C
3: 78 percent / H2 / 10percent Pd/C / methanol / 1.5 h / Ambient temperature
4: 1.) 1 N HCl, NaNO2 / 1.) acetone, 0 deg C, 15 min, 2.) acetone, H2O, 10 deg C, 1.5 h
With
hydrogenchloride; thionyl chloride; hydrogen; sodium nitrite;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00118a031
