606-45-1

Basic information

• Product Name: Methyl 2-methoxybenzoate
• Synonyms: RARECHEM AL BF 0022;O-ANISIC ACID METHYL ESTER;2-methoxy-benzoicacimethylester;o-methoxymethylbenzoate;METHYL-O-METHOXYBENZOATE;METHYL O-ANISATE;METHYL 2-ANISATE;METHYL 2-METHOXYBENZOATE
• CAS NO: 606-45-1
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• EINECS: 210-118-6
• Product Categories: Aromatic Esters
• Mol File: 606-45-1.mol
• Article Data: 126

Chemical Properties

• Boiling Point: 248 °C(lit.)
• Flash Point: >230 °F
• Appearance: clear colorless to slightly yellow liquid
• Density: 1.157 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000722mmHg at 25°C
• Refractive Index: n20/D 1.534(lit.)
• Storage Temp.: Store below +30°C.
• BRN: 2207356
• CAS DataBase Reference: Methyl 2-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-methoxybenzoate(606-45-1)
• EPA Substance Registry System: Methyl 2-methoxybenzoate(606-45-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 2
• RTECS: DH3549000
• TSCA: Yes
• Hazardous Substances Data: 606-45-1(Hazardous Substances Data)

Usage

Description

METHYL ο-METHOXYBENZOATE has a herbaceous, anise-like odor with a sweet taste reminiscent of melon. May be prepared by esterification of anisic acid with methanol; or from sodium anisate and dimethylsulfate in the presence of methanol.

Chemical Properties

Different sources of media describe the Chemical Properties of 606-45-1 differently. You can refer to the following data:
1. Methyl o-methoxybenzoate has an herbaceous, warm, anise-like odor and a sweet taste reminiscent of melon
2. clear colorless to slightly yellow liquid

Occurrence

Reported found in a grape and mushroom variety, Trametes graveolens, Vitis labrusca L. and black tea.

Uses

Methyl 2-methoxybenzoate has been used in the synthesis of (+/?)-vibralactone.

Preparation

By esterification of anisic acid with methanol, or from sodium anisate and dimethylsulfate in the presence of methanol

Aroma threshold values

Aroma characteristics at 1.0%: fruity, winey, fermented with a slightly musty and anisic nuance.

Taste threshold values

Taste characteristics at 10 ppm: fruity, anisic, fermented and winey with a good mouthfeel

General Description

FeCl2 catalyzed cross-coupling reaction between methyl 2-methoxybenzoate and diphenylmethane under various reaction conditions has been investigated.

InChI:InChI=1/C9H12O3/c1-9(12-2)6-4-3-5-7(9)8(10)11/h3-7H,1-2H3,(H,10,11)/p-1

Synthetic route

dimethyl sulfate (77-78-1) + salicylic acid (69-72-7) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With potassium carbonate In acetone at 50 - 60℃; for 27h; Time; Large scale;	99%
With potassium carbonate In acetone at 0 - 10℃; for 4h; Reflux; Inert atmosphere;	91.1%
With potassium carbonate In acetone at 20℃; for 3.16667h; Heating / reflux;	80%

methanol (67-56-1) + 2-Methoxybenzoic acid (579-75-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With thionyl chloride at 20℃; for 18h; Cooling with ice; Inert atmosphere;	99%
With Oxone In toluene at 60℃; for 48h; Green chemistry;	97%
With 2-(dimethoxymethylidene)propanedinitrile at 60℃; for 48h;	95%

methanol (67-56-1) + 2-bromoanisole (578-57-4) + carbon monoxide (201230-82-2) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With dichloro[2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II); triethylamine at 100℃; under 2585.74 Torr; for 16h;	99%

2-Methoxybenzoic acid (579-75-9) + carbonic acid dimethyl ester (616-38-6) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With 5 wt percent zeolite NaY-Bf at 200℃; for 5h; Autoclave; Green chemistry;	98%
With potassium carbonate In dimethyl sulfoxide at 90℃; for 16h; Inert atmosphere; Green chemistry;	96%

carbonic acid dimethyl ester (616-38-6) + salicylic acid (69-72-7) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With diiron nonacarbonyl at 180℃; for 1h; Sealed tube;	97%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0208333h; microwave irradiation;	92%
With potassium carbonate at 150℃; for 10h;

methanol (67-56-1) + ortho-anisaldehyde (135-02-4) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With perchloric acid; sodium percarbonate; vanadia for 1.3h; Cooling;	96%
With dihydrogen peroxide at 20℃; for 20h;	95%
With aluminium(III) chloride hexahydrate; urea hydrogen peroxide adduct at 60℃; Green chemistry;	90%

methanol (67-56-1) + 4-iodoanisol (529-28-2) + carbon monoxide (201230-82-2) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With triethylamine at 100℃; under 3750.38 Torr; for 1.5h; Inert atmosphere;	96%
With triethylamine; palladium on activated charcoal at 130℃; under 3750.38 Torr; for 2h; Sonogashira coupling;	77%
With triethylamine; G1-C2 PAMAM dendrimer*PPh2*PdCl2 at 105℃; under 5171.62 Torr; for 19h;	100 % Chromat.

methanol (67-56-1) + (2-methoxyphenyl)methanol (612-16-8) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With bismuth(III) chloride; palladium diacetate; potassium carbonate at 20℃; for 2h; chemoselective reaction;	95%
With sodium methylate; potassium iodide at 15℃; Electrochemical reaction;	85%
With oxygen; potassium carbonate at 70℃; under 750.075 Torr; for 48h;	53%

methyl bromide (74-83-9) + salicylic acid (69-72-7) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With potassium hydroxide In water at 15 - 20℃; Concentration; Temperature;	94%
With sodium hydroxide In water at 20 - 25℃; Temperature;	94%
With sodium hydroxide In water at 11 - 20℃; Temperature; Cooling;	94%

methyl 2-hydroxy-5-nitrobenzoate (17302-46-4) + 2-Methoxybenzoic acid (579-75-9) → 2-methoxybenzoic acid methyl ester (606-45-1) + 5-nitrosalicylic acid (96-97-9)

Conditions	Yield
Stage #1: 2-Methoxybenzoic acid With potassium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h; Stage #2: methyl 2-hydroxy-5-nitrobenzoate at 110℃; for 24h;	A 93% B n/a

2-Methoxybenzoic acid (579-75-9) + methyl salicylate (119-36-8) → 2-methoxybenzoic acid methyl ester (606-45-1) + salicylic acid (69-72-7)

Conditions	Yield
Stage #1: 2-Methoxybenzoic acid With potassium carbonate In N,N-dimethyl acetamide at 110℃; for 0.5h; Stage #2: methyl salicylate at 110℃; for 24h; Solvent; Reagent/catalyst; Temperature;	A 92% B n/a

salicylic acid (69-72-7) + methyl iodide (74-88-4) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With potassium carbonate In acetone Heating;	91%
With silver(l) oxide; benzene
With potassium hydroxide; Aliquat 336 1.) 60 deg C, 0.1 Torr, 6 h, 2.) room temp., 24 h; Yield given. Multistep reaction;
With potassium carbonate In N,N-dimethyl-formamide at 90℃;
With potassium carbonate In acetone at 20℃; Reflux; Darkness;

methanol (67-56-1) + N-(2-methoxybenzoyl)-N-phenylhydroxylamine (34661-16-0) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With sodium perchlorate In acetonitrile electrolysis;	87%

Methyltrimethoxysilan (1185-55-3) + o-iodo-methyl-benzoic acid (610-97-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With oxygen; copper diacetate; caesium carbonate In N,N-dimethyl-formamide at 145℃; under 760.051 Torr; for 18h;	86%

Methoxytrimethylsilane (1825-61-2) + 2-bromobenzoic acid methyl ester (610-94-6) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With oxygen; copper diacetate; caesium carbonate In N,N-dimethyl-formamide at 145℃; under 760.051 Torr; for 18h;	86%

methanol (67-56-1) + 2-Methoxybenzoyl chloride (21615-34-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
In dichloromethane for 2h; Heating;	85%
With pyridine for 2h; Yield given;
With triethylamine In dichloromethane at 0℃;
With triethylamine In dichloromethane at 0℃; Inert atmosphere;	1.56 g

methanol (67-56-1) + 2-bromoanisole (578-57-4) + carbon monoxide (201230-82-2) → 2-methoxybenzoic acid methyl ester (606-45-1) + 2-Methoxybenzoic acid (579-75-9)

Conditions	Yield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 20h; Irradiation;	A 84.5% B 8%

2-bromoanisole (578-57-4) + carbon monoxide (201230-82-2) → 2-methoxybenzoic acid methyl ester (606-45-1) + 2-Methoxybenzoic acid (579-75-9)

Conditions	Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 20h; Irradiation;	A 84.5% B 8%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2-Chloroanisole (766-51-8) + lithium methanolate (865-34-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With 1,1'-bis-(diphenylphosphino)ferrocene; 5 mol% Pd/C; sodium fluoride In 1,4-dioxane at 150℃; Inert atmosphere;	83%

methyl iodide (74-88-4) + methyl salicylate (119-36-8) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
Stage #1: methyl salicylate With sodium hydride In N,N-dimethyl-formamide at 0℃; for 0.333333h; Stage #2: methyl iodide In N,N-dimethyl-formamide at 20℃; for 15h;	81%
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 4h;	74%
With potassium hydroxide In methanol for 3h; Reflux;	53%
With methanol; sodium methylate
With potassium carbonate; potassium iodide In acetone Reflux;

diazomethyl-trimethyl-silane (18107-18-1) + methyl salicylate (119-36-8) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In methanol; hexane; acetonitrile for 15h; Ambient temperature;	78%

dihydroxy-methyl-borane (13061-96-6) + 2-Methoxybenzoic acid (579-75-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With pyridine; copper (II) carbonate hydroxide at 90℃; for 24h; Chan-Lam Coupling;	78%

methanol (67-56-1) + 2-Chloroanisole (766-51-8) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With 1,3-bis(dicyclohexylphosphino)propane bis(tetrafluoroborate) salt; palladium diacetate; potassium carbonate In dimethyl sulfoxide at 120℃; for 20h; Molecular sieve;	74%

tert.-butylhydroperoxide (75-91-2) + 2-methoxybenzylamine (6850-57-3) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
Stage #1: tert.-butylhydroperoxide; 2-methoxybenzylamine In water; dimethyl sulfoxide Stage #2: In water; dimethyl sulfoxide at 100℃; for 20h; Sealed tube;	74%

dimethyl sulfate (77-78-1) + methyl salicylate (119-36-8) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With lithium hydroxide In tetrahydrofuran at 70℃; for 0.5h;	72%

O-methyl S-p-methylphenyl thiocarbonate (3186-53-6) + 2-Methoxyphenylboronic acid (5720-06-9) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane In 1,4-dioxane at 60℃; for 16h; Sealed tube; Inert atmosphere;	70%

methyl 2,6-dimethoxybenzoate (2065-27-2) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With bis(1,5-cyclooctadiene)nickel (0); 1,1,3,3-Tetramethyldisiloxane; tricyclohexylphosphine In toluene at 110℃; for 12h; Glovebox; Inert atmosphere; Sealed tube;	68%

tert.-butylhydroperoxide (75-91-2) + ortho-anisaldehyde (135-02-4) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With copper (II)-fluoride In water; dimethyl sulfoxide at 120℃; for 12h; Schlenk technique; Inert atmosphere; Green chemistry;	67%

methanol (67-56-1) + 1-(2-methoxyphenyl)ethanol (13513-82-1) → 2-methoxybenzoic acid methyl ester (606-45-1)

Conditions	Yield
With N-iodo-succinimide; 1,10-Phenanthroline; oxygen; potassium carbonate; copper dichloride In dimethyl sulfoxide at 140℃; under 3750.38 Torr; for 24h; Molecular sieve;	60%
With oxygen; potassium carbonate at 150℃; under 4500.45 Torr; for 24h; Autoclave;	84 %Chromat.

methanol (67-56-1) + methoxybenzene (100-66-3) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → 2-methoxybenzoic acid methyl ester (606-45-1) + ortho-anisaldehyde (135-02-4)

Conditions	Yield
Stage #1: methoxybenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -78 - 20℃; for 2h; Stage #3: methanol Further stages;	A 53% B 6%

pyrrolidine (123-75-1) + 2-methoxybenzoic acid methyl ester (606-45-1) → (2-methoxyphenyl)(pyrrolidin-1-yl)methanone (120173-04-8)

Conditions	Yield
In acetonitrile at 35℃; under 6000480 Torr; for 96h;	100%

2-methoxybenzoic acid methyl ester (606-45-1) → methyl 2-methoxy-5-iodobenzoate (40757-09-3)

Conditions	Yield
With iodine; silver sulfate In methanol at 20℃; for 0.5h; Inert atmosphere;	99%
With gold(III) chloride; N-iodo-succinimide In dichloromethane at 20℃; for 24h; Inert atmosphere;	96%
With N-iodo-succinimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In dichloromethane; toluene at 20℃; for 14h; regioselective reaction;	91%

2-methoxybenzoic acid methyl ester (606-45-1) → methyl 5-bromo-2-methoxybenzoate (7120-41-4)

Conditions	Yield
With N-Bromosuccinimide; silver hexafluoroantimonate; 1-methylthiotriptycene In 1,2-dichloro-ethane at 20℃; for 1h; Inert atmosphere; Schlenk technique;	99%
With gold(III) chloride; N-Bromosuccinimide In dichloromethane at 80℃; for 23h; Inert atmosphere;	96%
With iodine pentoxide; potassium bromide In water at 20℃; for 20h; regioselective reaction;	92%

acetic acid tert-butyl ester (540-88-5) + 2-methoxybenzoic acid methyl ester (606-45-1) → tert-butyl 2-methoxybenzoate (16537-20-5)

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran Ambient temperature;	98%

2-methoxybenzoic acid methyl ester (606-45-1) + dimethyl methane phosphonate (756-79-6) → dimethyl [2-(2-methoxyphenyl)-2-oxoethyl]phosphonate (918874-30-3)

Conditions	Yield
With lithium hexamethyldisilazane In tetrahydrofuran Barbier reaction; Cooling with ice; Inert atmosphere;	97%
With n-butyllithium In tetrahydrofuran at -78 - 0℃; Inert atmosphere;

ethanol (64-17-5) + 2-methoxybenzoic acid methyl ester (606-45-1) → ethyl 2-methoxybenzoate (7335-26-4)

Conditions	Yield
With platinum(IV) oxide; hydrogen at 60℃; under 750.075 - 1500.15 Torr; for 16h; Autoclave; Green chemistry; chemoselective reaction;	97%

2-methoxybenzoic acid methyl ester (606-45-1) → methyl salicylate (119-36-8)

Conditions	Yield
With aluminium trichloride; sodium iodide at 70 - 80℃; for 2h;	95%
With aluminum (III) chloride In dichloromethane at -5 - 25℃;	94%
With aluminium(III) iodide In carbon disulfide for 0.9h; Heating;	76%
With cerium(III) chloride; sodium iodide In acetonitrile for 20h; dealkylation; Heating;	67%
With niobium pentachloride In 1,2-dichloro-ethane for 6h; Heating;

2-methoxybenzoic acid methyl ester (606-45-1) + bis(pinacol)diborane (73183-34-3) → 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1146214-77-8)

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 2-(dimethyl(phenyl)silyl)-1-(6-methoxypyridin-2-yl)-2,3-dihydro-1H-naphtho[1,8-de]-[1,3,2]diazaborinine In hexane at 80℃; for 20h; Time; Schlenk technique; Inert atmosphere;	95%
With silica-SMAP-Ir(OCH3)(C8H12) In hexane ligand reacted with B-compound in hexane in presence of Ir-complex as catalyst at 25°C for 2 h;	85%
With Silica-SMAP-Ir(OMe)(cod) In hexane at 25℃; for 2h; Autoclave; regioselective reaction;	85%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; (2-(diisopropylsilyl)phenyl)di-p-tolylphosphane In tetrahydrofuran at 80℃; for 16h; Inert atmosphere; Glovebox; Sealed tube;	82%
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; (2-(diisopropylsilyl)phenyl)di-p-tolylphosphane In tetrahydrofuran at 80℃; Inert atmosphere;

2-methoxybenzoic acid methyl ester (606-45-1) → 2-Methoxybenzoic acid (579-75-9)

Conditions	Yield
Stage #1: 2-methoxybenzoic acid methyl ester With sodium hydroxide In methanol; water for 2h; Reflux; Stage #2: With hydrogenchloride In methanol; water pH=1;	94%
With sodium hydroxide In methanol at 40℃; for 2.5h;	94.3%
With potassium hydroxide In methanol at 35℃; for 1h;	93%

2-methoxybenzoic acid methyl ester (606-45-1) → 2-methoxybenzoylhydrazine (7466-54-8)

Conditions	Yield
With hydrazine hydrate In ethanol for 4h; Reflux;	94%
With hydrazine hydrate In ethanol at 80℃; for 1h; Inert atmosphere;	92%
With hydrazine hydrate for 5h; Heating;	90%

[hydroxy(tosyloxy)iodo]benzene (27126-76-7) + 2-methoxybenzoic acid methyl ester (606-45-1) → phenyl(4-methoxy-3-methoxycarbonylphenyl)iodonium tosylate

Conditions	Yield
In 2,2,2-trifluoroethanol at 20℃; for 17h;	94%

Diphenylmethane (101-81-5) + 2-methoxybenzoic acid methyl ester (606-45-1) → benzophenone (119-61-9) + methyl 5-benzhydryl-2-methoxybenzoate (1169764-31-1) + 1,1,2,2-tetraphenylethane (632-50-8)

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; iron(II) chloride In 1,2-dichloro-ethane at 100℃; for 36h; Inert atmosphere; regioselective reaction;	A 0.14 mmol B 94% C 0.07 mmol

1-methyl-4-(phenylmethyl)benzene (620-83-7) + 2-methoxybenzoic acid methyl ester (606-45-1) → methyl 2-methoxy-5-(phenyl(p-tolyl)methyl)benzoate (1169764-40-2)

Conditions	Yield
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; iron(II) chloride In 1,2-dichloro-ethane at 100℃; for 36h; Inert atmosphere; regioselective reaction;	94%

methanesulfonic acid (75-75-2) + hexamethylenetetramine (100-97-0) + 2-methoxybenzoic acid methyl ester (606-45-1) → methyl 5-formyl-2-methoxybenzoate (78515-16-9)

Conditions	Yield
at 0 - 90℃; for 16h; Temperature; Large scale;	94%

2-methoxybenzoic acid methyl ester (606-45-1) → salicylic acid (69-72-7)

Conditions	Yield
With AlBrCl3(1-)*C5H5N*H(1+) at 140℃; for 3h;	93%
With lithium chloride In N,N-dimethyl-formamide for 22h; Heating;	90%
With iodine; aluminium In cyclohexane at 80℃; for 18h; Solvent; Reagent/catalyst;	86%

2-methoxybenzoic acid methyl ester (606-45-1) + (p-fluorophenyl)trimethylsilane (455-17-4) → 4'-fluoro-4-methoxy-biphenyl-3-carboxylic acid methyl ester (64465-74-3)

Conditions	Yield
With (Ph3P)Au(I)(OTs); [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid In methanol; chloroform at 20℃;	92%

trifluorormethanesulfonic acid (1493-13-6) + 2-methoxybenzoic acid methyl ester (606-45-1) → C18H18IO6(1+)*CF3O3S(1-)

Conditions	Yield
With iodine; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 6h; Sealed tube;	92%
With iodine; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 0 - 20℃; for 6h;	92%
With iodine; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 6h;	92%

2-methoxybenzoic acid methyl ester (606-45-1) → 1-methoxy-2-methoxymethylbenzene (21998-86-7)

Conditions	Yield
With aluminium(III) triflate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In deuteromethanol; toluene at 130℃; under 30402 Torr; for 12h; Autoclave;	91%

Upstream product

• 67-56-1 methanol 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 512-42-5 sodium methyl sulfate 
• 7631-93-8 sodium o-methoxycarbonylphenolate 
• 578-57-4 2-bromoanisole 
• 201230-82-2 carbon monoxide 
• 579-75-9 2-Methoxybenzoic acid 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 303-38-8 2,3-Dihydroxybenzoic acid 
• 490-79-9 2,5-dihydroxybenzoic acid. 
• 99-06-9 3-Carboxyphenol 

Downstream Products

• 92242-74-5 6-carbomethoxy-6-isopropyl-1-methoxy-1,4-cyclohexadiene 
• 92242-75-6 6-benzyl-6-carbomethoxy-1-methoxy-1,4-cyclohexadiene 
• 1015779-41-5 2-methoxy-1-(3-methyl-but-2-enyl)-cyclohexa-2,5-diene-1-carboxylic acid methyl ester 
• 21022-73-1 2-(2'-methoxyphenyl)-2-propanol 
• 1146214-77-8 2-methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester 
• 1374979-30-2 C₁₅H₁₈BrN₃O₂ 
• 62536-78-1 7-methoxy-2-(2-methoxyphenyl)-4H-chromen-4-one 
• 77298-66-9 7,2'-dihydroxyflavone 
• 860586-17-0 1,2-bis-(2-methoxy-phenyl)-1,1,2,2-tetraphenyl-ethane 
• 857601-28-6 o-monomethoxytrityl chloride 
• 64655-66-9 Diphenyl-(2-methoxy-phenyl)-methyl 
• 5561-92-2 1-(2-methoxyphenyl)propan-1-one 
• 423120-28-9 5-(α-bromo-isobutyryl)-2-methoxy-benzoic acid 
• 439145-87-6 5-isobutyryl-2-methoxy-benzoic acid 

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Under microwave irradiation (MWI), novel chiral receptors derived from deoxycholic acid were synthesized by using deoxycholic acid methyl ester as the spacer, and arylhydrazine and amino acids as the arm. Selective recognition properties of these receptors for aromatic amines and D/L-amino acids have been investigated by UV-vis spectral titration and 1H NMR spectral study. The results indicate this type of receptors can form a 1:1 supramolecular complex with an aromatic amine and a 1:2 supramolecular complex with D/L-tryptophan.

Method for preparing carboxylic ester compounds by oxidizing and breaking carbon-carbon bonds of secondary alcohol compounds

The invention discloses a method for preparing carboxylic ester compounds by oxidizing and breaking carbon-carbon bonds of secondary alcohol compounds. The method comprises the following steps: adding a secondary alcohol compound, an additive and a nitrogen-doped mesoporous carbon loaded monatomic catalyst into a fatty primary alcohol solvent, putting into a pressure container, sealing, introducing oxygen source gas with a certain pressure, controlling the pressure of the oxygen source gas to be 0.1-1 MPa and the reaction temperature to be 80-150 DEG C, and obtaining a product after the reaction to be the carboxylic ester compound. The nitrogen-doped mesoporous carbon-loaded monatomic catalyst adopted by the invention is high in activity, the highest separation yield of the carboxylic ester compound as a reaction product reaches 99%, the method is wide in application range, the reaction conditions are easy to control, the catalyst can be recycled, the post-treatment is simple, and the method is suitable for industrial production.

Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives

Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects againstXac,Psa, andXoo. EC50data exhibited that A8 (19.7 μg/mL) had better antibacterial activity againstXoothan myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the bestin vivoantiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 ± 0.001 μmol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 ± 1.301 μmol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.