<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Base Information

Chemical Name:<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide
CAS No.:205526-97-2
Molecular Formula:C₃₀H₄₁N₃O₄
Molecular Weight:507.673
Hs Code.:

<4-<N-(benzyloxy)amino>-2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Synonyms:<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Suppliers and Price of <4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of <4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of <4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

There total 4 articles about <4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155947-71-0
benzyl 2<(benzyloxy)carbonyl>-3(R)-(hydroxycarbonyl)-5-methylhexanoate

: 205526-97-2
<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Guidance literature:: Multi-step reaction with 4 steps

1: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / Ambient temperature

2: 1.) H₂, 2.) piperidine, H₂O / 1.) 10 percent Pd/C / 1.) EtOH, RT, 4 h, 2.) EtOH, a) RT, 16 h, b) reflux, 1 h

3: H₂ / 10 percent Pd/C / methanol / Ambient temperature

4: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

With piperidine; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970404a

Reference yield:

: 1025990-16-2
(R)-5-Methyl-3-[(S)-1-methylcarbamoyl-2-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethylcarbamoyl]-2-methylene-hexanoic acid

: 205526-97-2
<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / methanol / Ambient temperature

2: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970404a

Reference yield:

: 1026461-08-4
2-{(R)-3-Methyl-1-[(S)-1-methylcarbamoyl-2-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethylcarbamoyl]-butyl}-malonic acid dibenzyl ester

: 205526-97-2
<4--2(R)-isopropyl-3(S)-methylsuccinyl>-L-3-(5,6,7,8-tetrahydro-1-naphthyl)alanine-N-methylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) H₂, 2.) piperidine, H₂O / 1.) 10 percent Pd/C / 1.) EtOH, RT, 4 h, 2.) EtOH, a) RT, 16 h, b) reflux, 1 h

2: H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: HOBT*H₂O, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, Et₃N / dimethylformamide / 12 h / Ambient temperature

With piperidine; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970404a