1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene

Base Information

• Chemical Name: 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene
• CAS No.: 178232-89-8
• Molecular Formula: C₁₄H₂₁NO₃S
• Molecular Weight: 283.392
• Mol file: 178232-89-8.mol

Synonyms:1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene

Chemical Property of 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene

There total 2 articles about 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-(S)-dimethyl-p-tolylsulfinylmethanephosphonate (63268-43-9) → 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene (178232-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2: 601 mg / DBU / 28 h / Ambient temperature

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; hexane;

DOI:10.1021/jo960228y

Reference yield:

2-nitropropane (79-46-9) + (R)-[(Z)-1-butenyl] p-tolyl sulfoxide (73803-24-4) → 1-((R)-(S)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene (178232-90-1) + 1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene (178232-89-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; for 28h; Ambient temperature;

DOI:10.1021/jo960228y

Reference yield: 87.0%

1-((R)-(R)-2-Ethyl-3-methyl-3-nitro-butane-1-sulfinyl)-4-methyl-benzene (178232-89-8) → (R,R)-1-(p-tolylsulfinyl)-2-ethyl-3-deuterio-3-methylbutane (178232-91-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tributyltin deuteride; In benzene; at 85 ℃; for 6h;

DOI:10.1021/jo960228y

upstream raw materials:

2-nitropropane

(R)-[(Z)-1-butenyl] p-tolyl sulfoxide

(+)-(S)-dimethyl-p-tolylsulfinylmethanephosphonate

Downstream raw materials:

(R,R)-1-(p-tolylsulfinyl)-2-ethyl-3-deuterio-3-methylbutane

(R)-1-(p-tolylsulfonyl)-2-ethyl-3-deuterio-3-methylbutane