N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide

Base Information

• Chemical Name: N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide
• CAS No.: 1007308-30-6
• Molecular Formula: C₂₂H₂₅ClN₄O₄
• Molecular Weight: 444.918

Synonyms:N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide

Chemical Property of N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide

Chemical Property:

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Technology Process of N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide

There total 1 articles about N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.9%

N-[4-(3-chloro-4-methoxy-benzylamino)-7-methoxy-8-(2-oxo-ethyl)-quinazolin-6-yl]-propionamide → N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide (1007308-30-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 1h;

Reference yield: 93.0%

N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide (1007308-30-6) + tert-butyldimethylsilyl chloride (18162-48-6) → C28H39ClN4O4Si

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide (1007308-30-6) → C19H21ClN4O3 (1007308-85-1)

Guidance literature:

N-[4-(3-chloro-4-methoxy-benzylamino)-8-(2-hydroxy-ethyl)-7-methoxy-quinazolin-6-yl]-propionamide; With hydrogenchloride; methanol; water; for 15h; Heating / reflux;

With sodium hydroxide; In water; pH=7.0 - 7.5;

Downstream raw materials:

C₁₉H₂₁ClN₄O₃

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