2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

Base Information

Chemical Name:2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one
CAS No.:1307741-11-2
Molecular Formula:C₂₈H₂₅F₆NO₃
Molecular Weight:537.502
Hs Code.:

Synonyms:2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

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Chemical Property of 2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

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Technology Process of 2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

There total 6 articles about 2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: N-[4-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-3-hydroxyphenyl]-N-butyl-2-iodobenzamide

: 74-88-4
methyl iodide

: 1307741-11-2
2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307740-94-8
2-(4-butylamino-2-methoxyphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol

: 1307741-11-2
2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

3.1: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / 2,4-dichlorophenoxyacetic acid dimethylamine / 2 h / 165 °C / Inert atmosphere

4.1: potassium carbonate / dichloromethane / 3 h / 0 °C

With palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; triethylamine; tricyclohexylphosphine tetrafluoroborate; In dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.002

Reference yield:

: 1307741-03-2
N-butyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3-methoxyphenyl]-2-iodo-benzamide

: 1307741-11-2
2-(2-benzyloxy-1,1,1,3,3,3-hexafluoropropan-2-yl)-5-butyl-1-methoxyphenanthridin-6(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate / 2,4-dichlorophenoxyacetic acid dimethylamine / 2 h / 165 °C / Inert atmosphere

3.1: potassium carbonate / dichloromethane / 3 h / 0 °C

With palladium diacetate; sodium hydride; potassium carbonate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate; In dichloromethane; 2,4-dichlorophenoxyacetic acid dimethylamine; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.002