5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

Base Information

Chemical Name:5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole
CAS No.:109105-53-5
Molecular Formula:C₂₁H₂₂BrNO₅S
Molecular Weight:480.379
Hs Code.:

Synonyms:5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

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Chemical Property of 5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

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Technology Process of 5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

There total 1 articles about 5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 109105-52-4
5-bromo-4-(3-ethoxycarbonyl-2-oxopropyl)-4-hydroxy-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

: 109105-53-5
5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

Guidance literature:: With toluene-4-sulfonic acid; In chloroform; a) RT, 20 min, b) 50 deg C, 40 min;
DOI:10.3987/R-1986-11-3149

Reference yield: 99.0%

: 109105-53-5
5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

: 109105-54-6
4-(3-ethoxycarbonyl-2-oxopropyl)-1-(p-toluenesulfonyl)indole

Guidance literature:: With lithium bromide; In N,N-dimethyl-formamide; at 85 ℃; for 2h;
DOI:10.3987/R-1986-11-3149

Reference yield:

: 109105-53-5
5-bromo-4-(3-ethoxycarbonyl-2-oxopropylidene)-1-(p-toluenesulfonyl)-4,5,6,7-tetrahydroindole

: 4-(6-ethoxycarbonyl-2-methyl-5-oxohex-1-en-4-yl)-1-(p-toluenesulfonyl)indole

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / LiBr / dimethylformamide / 2 h / 85 °C

2: 1.) NaH, BuLi / 1.) THF, hexane, 2.) THF, hexane, 0 deg C, 20 min

With n-butyllithium; sodium hydride; lithium bromide; In N,N-dimethyl-formamide;
DOI:10.3987/R-1986-11-3149