N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

Base Information

Chemical Name:N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid
CAS No.:1092690-96-4
Molecular Formula:C₂₆H₂₈N₂O₇S
Molecular Weight:512.584
Hs Code.:

Synonyms:N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

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Chemical Property of N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

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Technology Process of N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

There total 8 articles about N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1092690-93-1
N-(4-phenoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

: 1092690-96-4
N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm800964f

Reference yield:

: 1092690-90-8
N-(4-phenoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-D-valine

: 1092690-96-4
N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine / tetrahydrofuran / 0 °C

2: methanol / 0 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200593b

Reference yield:

: 1092690-85-1
N-(4-phenoxybenzenesulfonyl)-O-benzyl-D-valine

: 1092690-96-4
N-(4-phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3: 4-methyl-morpholine / tetrahydrofuran / 0 °C

4: methanol / 0 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; potassium carbonate; trifluoroacetic acid; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm200593b