N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide

Base Information

• Chemical Name: N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide
• CAS No.: 77391-30-1
• Molecular Formula: C₁₁H₁₄FN₃O*HI
• Molecular Weight: 351.163
• Mol file: 77391-30-1.mol

Synonyms:N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide

Chemical Property of N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide

There total 2 articles about N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + 1-(4-Fluoro-phenyl)-2-methyl-isothiourea; hydriodide (21722-13-4) → N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide (77391-30-1)

Guidance literature:

With triethylamine; In tert-butyl alcohol; for 4h; Heating;

DOI:10.1055/s-1988-27606

Reference yield:

(4-fluoro-phenyl)-thiourea (459-05-2) → N-(4-Fluoro-phenyl)-morpholine-4-carboxamidine; hydriodide (77391-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / methanol / 2 h / Ambient temperature

2: 71 percent / N(C₂H₅)3 / 2-methyl-propan-2-ol / 4 h / Heating

With triethylamine; In methanol; tert-butyl alcohol;

DOI:10.1055/s-1988-27606

upstream raw materials:

morpholine

1-(4-Fluoro-phenyl)-2-methyl-isothiourea; hydriodide

(4-fluoro-phenyl)-thiourea