2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID
• CAS No.: 7347-97-9
• Molecular Formula: C₅H₉NO₂S
• Molecular Weight: 147.198
• Mol file: 7347-97-9.mol

Synonyms:

Chemical Property of 2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.71E-05mmHg at 25°C
• Melting Point: >160°C (Subl.)
• Boiling Point: 333°C at 760 mmHg
• Flash Point: 155.2°C
• Density: 1.263g/cm³
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

• Uses: An Cysteine prodrug, protective aginst the fungal T-2 toxin. It is also a precursor to pharmaceuticals used in the treatment of cataracts.

Technology Process of 2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID

There total 8 articles about 2-METHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + cysteine → (4R)-2-Methyl-1,3-thiazolidine-4-carboxylic acid (190062-99-8,7347-97-9,88855-01-0,88855-02-1,88855-03-2,88855-04-3)

Guidance literature:

cysteine; With potassium acetate; In methanol; for 0.166667h;

formaldehyd; In methanol; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 92.0%

L-Cysteine (52-90-4) + acetaldehyde (75-07-0,9002-91-9) → (4R)-2-Methyl-1,3-thiazolidine-4-carboxylic acid (190062-99-8,7347-97-9,88855-01-0,88855-02-1,88855-03-2,88855-04-3)

Guidance literature:

With potassium acetate; In methanol; water; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.jafc.6b05805

Reference yield: 62.0%

D-cysteine (921-01-7) + acetaldehyde (75-07-0,9002-91-9) → 2(R,S)-methylthiazolidine-4(R)-carboxylic acid (205985-91-7,7347-97-9,88855-01-0,88855-02-1,88855-03-2,88855-04-3)

Guidance literature:

In water; for 1h;

DOI:10.1021/jm00371a006

upstream raw materials:

acetaldehyde

rac-cysteine

l-cysteine hydrochloride

L-Cysteine

Downstream raw materials:

(R)-3-(2-Benzyloxycarbonylamino-acetyl)-2-methyl-thiazolidine-4-carboxylic acid