(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

Base Information

Chemical Name:(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate
CAS No.:172479-59-3
Molecular Formula:C₁₆H₂₂N₂O₅
Molecular Weight:322.361
Hs Code.:

Synonyms:(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

There total 4 articles about (2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: methyl (S)-N²-[(tert-butoxycarbonylamino)-N⁴-phenylamino]-4-oxobutanoate

: (2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(4'-aminophenyl)butanoate

: 172479-59-3
(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

Guidance literature:: In acetonitrile; Inert atmosphere; UV-irradiation;
DOI:10.1055/s-0040-1707223

Reference yield:

: 201230-82-2
carbon monoxide

: 615-43-0
2-iodophenylamine

: (R)-(2-((tert-butoxycarbonyl)amino)-3-methoxy-3-oxopropyl)zinc(II)iodide

: 172479-59-3
(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 30h; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1039/c39950002207

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₁H₁₄N₂O₃*ClH

: (2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(4'-aminophenyl)butanoate

: 172479-59-3
(2S)-Methyl 2-(N-tert-butoxycarbonylamino)-4-oxo-4-(2'-aminophenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / isopropyl alcohol / 24 h / 20 °C / Inert atmosphere

2: acetonitrile / Inert atmosphere; UV-irradiation

With triethylamine; In isopropyl alcohol; acetonitrile; 2: |Fries Phenol Ester Rearrangement;
DOI:10.1055/s-0040-1707223