1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

Base Information

Chemical Name:1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine
CAS No.:1314114-21-0
Molecular Formula:C₂₀H₂₉NO₂
Molecular Weight:315.456
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

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Chemical Property of 1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

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Technology Process of 1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

There total 6 articles about 1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1314114-20-9
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

: 1314114-21-0
1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

Guidance literature:: With morpholine; bis(η3-allyl-μ-chloropalladium(II)); trifluoroacetic acid; triethyl phosphite; In 1,1-dichloroethane; for 10h; diastereoselective reaction; Reflux;
DOI:10.1002/anie.201100612

Reference yield:

: 1314114-19-6
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-3,4-dihydro-1H-azepin-2(7H)-one

: 1314114-21-0
1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: morpholine; bis(η3-allyl-μ-chloropalladium(II)); trifluoroacetic acid; triethyl phosphite / 1,1-dichloroethane / 10 h / Reflux

With morpholine; aluminum (III) chloride; lithium aluminium tetrahydride; bis(η3-allyl-μ-chloropalladium(II)); trifluoroacetic acid; triethyl phosphite; In tetrahydrofuran; 1,1-dichloroethane;
DOI:10.1002/anie.201100612

Reference yield:

: 1053660-70-0
C₁₆H₂₁NO₂

: 1314114-21-0
1-(4-methoxybenzyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)-2-vinylpyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: Hoveyda-Grubbs catalyst second generation

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

2.2: -78 - 20 °C

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4.1: morpholine; bis(η3-allyl-μ-chloropalladium(II)); trifluoroacetic acid; triethyl phosphite / 1,1-dichloroethane / 10 h / Reflux

With morpholine; aluminum (III) chloride; lithium aluminium tetrahydride; Hoveyda-Grubbs catalyst second generation; bis(η3-allyl-μ-chloropalladium(II)); trifluoroacetic acid; lithium diisopropyl amide; triethyl phosphite; In tetrahydrofuran; 1,1-dichloroethane;
DOI:10.1002/anie.201100612