1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

Base Information

Chemical Name:1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine
CAS No.:1314114-20-9
Molecular Formula:C₂₀H₂₉NO₂
Molecular Weight:315.456
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

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Chemical Property of 1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

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Technology Process of 1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

There total 5 articles about 1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1314114-19-6
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-3,4-dihydro-1H-azepin-2(7H)-one

: 1314114-20-9
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201100612

Reference yield:

: 1053660-70-0
C₁₆H₂₁NO₂

: 1314114-20-9
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Hoveyda-Grubbs catalyst second generation

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

2.2: -78 - 20 °C

3.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; Hoveyda-Grubbs catalyst second generation; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1002/anie.201100612

Reference yield:

: 1314114-12-9
1-(4-methoxybenzyl)-3,4-dihydro-1H-azepin-2(7H)-one

: 1314114-20-9
1-(4-methoxybenzyl)-3-((tetrahydro-2H-pyran-2-yl)methyl)-2,3,4,7-tetrahydro-1H-azepine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.08 h / -78 °C

1.2: -78 - 20 °C

2.1: lithium aluminium tetrahydride; aluminum (III) chloride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1002/anie.201100612