3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid

Base Information

• Chemical Name: 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid
• CAS No.: 1254703-66-6
• Molecular Formula: C₁₇H₁₅ClN₄O₂
• Molecular Weight: 342.785
• Mol file: 1254703-66-6.mol

Synonyms:3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid

Chemical Property of 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid

There total 2 articles about 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-chloro-6-hydrazinylpyridazine hydrochloride (856847-88-6) + 4,6-dioxo-6-(4-methylphenyl)hexanoic acid (114150-50-4) → 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid (1254703-66-6)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; Inert atmosphere; Reflux;

Reference yield:

para-methylacetophenone (122-00-9) → 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid (1254703-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0 °C

1.2: 0 - 55 °C

2.1: triethylamine / methanol / 20 °C / Inert atmosphere; Reflux

With potassium tert-butylate; triethylamine; In methanol; N,N-dimethyl-formamide;

Reference yield: 70.6%

4-Isopropylphenol (99-89-8) + 3-(1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl)propanoic acid (1254703-66-6) → 4-isopropylphenyl 3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]propanoate (1339035-44-7)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2011.08.009

upstream raw materials:

3-chloro-6-hydrazinylpyridazine hydrochloride

4,6-dioxo-6-(4-methylphenyl)hexanoic acid

para-methylacetophenone

Downstream raw materials:

C₁₇H₁₆N₄O₃

3-chloro-6-(5-(4-methylphenyl)-3-{3-oxo-3-[4-(tetrahydrofuran-2-ylmethyl)piperazin-1-yl]propyl}-1H-pyrazol-1-yl)pyridazine

3-[1-(6-chloropyridazin-3-yl)-5-(4-methylphenyl)-1H-pyrazol-3-yl]-N-(6-morpholin-4-ylpyridin-3-yl)propanamide

3-chloro-6-[3-{3-[4-(ethylsulfonyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]pyridazine