N-Boc-α,α-diphenylglycine

Base Information

• Chemical Name: N-Boc-α,α-diphenylglycine
• CAS No.: 160450-15-7
• Molecular Formula: C₁₉H₂₁NO₄
• Molecular Weight: 327.38
• Mol file: 160450-15-7.mol

Synonyms:N-Boc-α,α-diphenylglycine

Chemical Property of N-Boc-α,α-diphenylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-α,α-diphenylglycine

There total 7 articles about N-Boc-α,α-diphenylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + 2,2-diphenylglycine (3060-50-2) → N-Boc-α,α-diphenylglycine (160450-15-7)

Guidance literature:

With tetramethyl ammoniumhydroxide; In water; acetonitrile; for 96h; Inert atmosphere;

DOI:10.1021/jo9016138

Reference yield: 66.0%

tert-butyl 2-hydroxy-1,1-diphenylethylcarbamate → N-Boc-α,α-diphenylglycine (160450-15-7)

Guidance literature:

With ruthenium(IV) oxide; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 2h;

DOI:10.1055/s-0035-1560404

Reference yield:

phenylmagnesium bromide (100-58-3) → N-Boc-α,α-diphenylglycine (160450-15-7)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: sodium hydroxide / ethanol / 0.17 h / 135 °C / Microwave irradiation

3: ethanol / 2 h / 40 °C

4: sodium periodate; ruthenium(IV) oxide / acetonitrile; water; tetrachloromethane / 2 h / 20 °C

With ruthenium(IV) oxide; sodium periodate; sodium hydroxide; In tetrahydrofuran; tetrachloromethane; ethanol; water; acetonitrile;

DOI:10.1055/s-0035-1560404

upstream raw materials:

di-tert-butyl dicarbonate

2,2-diphenylglycine

phenylmagnesium bromide

2-amino-2,2-diphenylethan-1-ol

Downstream raw materials:

[diphenyl-(2-pyrrolidin-1-ylethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester