(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

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Chemical Name:(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol
CAS No.:1177258-94-4
Molecular Formula:C₄₁H₆₀O₄Si₂
Molecular Weight:673.096
Hs Code.:

Synonyms:(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

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Chemical Property of (+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

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Technology Process of (+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

There total 4 articles about (+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₆₂O₅Si₂

: 1177258-94-4
(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

Guidance literature:: With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol901437f

Reference yield:

: 1177258-83-1
2-(bromomethyl)phenethyl acetate

: 1177258-94-4
(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8 h / 80 °C / Inert atmosphere; Darkness

2: methanol; potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; toluene; 1: Stille coupling;
DOI:10.1021/ol901437f

Reference yield:

: 22532-46-3
2-(2-methylphenyl)ethyl acetate

: 1177258-94-4
(+)-2-(2-(((2R,4R)-2-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-(triisopropylsilyloxy)-3,4-dihydro-2H-pyran-6-yl)methyl)phenyl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / benzene / 6 h / Reflux; Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 8 h / 80 °C / Inert atmosphere; Darkness

3: methanol; potassium carbonate / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With methanol; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrahydrofuran; toluene; benzene; 2: Stille coupling;
DOI:10.1021/ol901437f