N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide
CAS No.:330796-29-7
Molecular Formula:C₂₅H₁₉F₄N₃O₂
Molecular Weight:469.438
Hs Code.:

Synonyms:N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

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Chemical Property of N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

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Technology Process of N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

There total 5 articles about N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 330796-26-4
3-(4-fluoro-phenyl)-2-(1-methylamino-ethyl)-3H-quinazolin-4-one

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 330796-29-7
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

Guidance literature:: 3-(4-fluoro-phenyl)-2-(1-methylamino-ethyl)-3H-quinazolin-4-one; 3-(Trifluoromethyl)benzoyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

With dmap; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 329190-49-0
2-(1-bromo-ethyl)-3-(4-fluoro-phenyl)-3H-quinazolin-4-one

: 330796-29-7
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 1 h / 40 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane;

Reference yield:

: 118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4
anthranilic acid

: 330796-29-7
N-{1-[3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-N-methyl-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 3.5 h / 140 °C

2.1: chloroform / Reflux

3.1: sodium acetate; acetic acid; bromine / 5 h / 40 °C / Inert atmosphere

4.1: ethanol / 1 h / 40 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

With bromine; sodium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; chloroform;