Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester

Base Information

• Chemical Name: Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester
• CAS No.: 212513-33-2
• Molecular Formula: C₄₄H₅₄O₇
• Molecular Weight: 694.909

Synonyms:Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester

Chemical Property of Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester

Chemical Property:

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Technology Process of Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester

There total 2 articles about Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

all-cis-6,9,12-octadecatrienoic acid (506-26-3,34615-07-1) → Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester (212513-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 0 - 23 °C

2: silver trifluoroacetate / tetrahydrofuran / 23 °C

With lithium aluminium tetrahydride; silver trifluoroacetate; In tetrahydrofuran;

DOI:10.1021/jm0100741

Reference yield:

methyl (2R)-2-methoxy-3-(triphenylmethoxy)propanoate (16814-88-3) → Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester (212513-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / DCC / CH₂Cl₂ / 2 h / 0 °C

2: silver trifluoroacetate / tetrahydrofuran / 23 °C

With silver trifluoroacetate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm0100741

Reference yield:

Malonic acid (R)-1-methoxycarbonyl-2-trityloxy-ethyl ester (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester (212513-33-2) → (R)-4-Hydroxy-2-oxo-5-trityloxymethyl-2,5-dihydro-furan-3-carboxylic acid (6Z,9Z,12Z)-octadeca-6,9,12-trienyl ester

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃;

DOI:10.1021/jm0100741

upstream raw materials:

all-cis-6,9,12-octadecatrienoic acid

methyl (2R)-2-methoxy-3-(triphenylmethoxy)propanoate

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