(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

Base Information

Chemical Name:(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid
CAS No.:200057-82-5
Molecular Formula:C₄₆H₇₀O₇Si
Molecular Weight:763.143
Hs Code.:

(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

Synonyms:(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

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Chemical Property of (R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

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Technology Process of (R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

There total 5 articles about (R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 200057-81-4
(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid methyl ester

: 200057-82-5
(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 50 ℃; for 2h;

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 200057-82-5
(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA / toluene / 24 h / 90 °C

2: KOMe / methanol; tetrahydrofuran / 1 h

3: 63 percent / DMAP, MS 4A, NEt₃ / CH₂Cl₂ / 28 h

4: 87 percent / aq. NaOH / tetrahydrofuran; methanol / 2 h / 50 °C

With dmap; sodium hydroxide; potassium methanolate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 21059-36-9
3α-ethoxycarbonyloxy-7α,12α-dihydroxy-5β-cholan-24-oic acid methyl ester

: 200057-82-5
(R)-4-[(3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Bis-benzyloxymethoxy-3-(tert-butyl-dimethyl-silanyloxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: DIPEA / toluene / 24 h / 90 °C

2: KOMe / methanol; tetrahydrofuran / 1 h

3: 63 percent / DMAP, MS 4A, NEt₃ / CH₂Cl₂ / 28 h

4: 87 percent / aq. NaOH / tetrahydrofuran; methanol / 2 h / 50 °C

With dmap; sodium hydroxide; potassium methanolate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;