2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Base Information

• Chemical Name: 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one
• CAS No.: 1374306-18-9
• Molecular Formula: C₂₁H₂₂F₃N₅O₂
• Molecular Weight: 433.433

Synonyms:2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Chemical Property of 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

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Technology Process of 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

There total 5 articles about 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + C17H14ClF3N4O (1374306-36-1) → 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-18-9)

Guidance literature:

In ethanol; at 150 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

3-cyclopropyl-1H-1,2,4-triazol-5-amine (502546-41-0) → 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-18-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 18 h / 75 °C

2: trichlorophosphate / 2 h / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

4: ethanol / 1 h / 150 °C / Microwave irradiation

With sodium ethanolate; potassium carbonate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

C8H6Cl2N4 (143315-03-1) → 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one (1374306-18-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 0.75 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3: ethanol / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.03.039

upstream raw materials:

morpholine

C₁₇H₁₄ClF₃N₄O

3-cyclopropyl-1H-1,2,4-triazol-5-amine

1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene

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