502546-41-0

Usage

Uses

Used in Pharmaceutical Research:
5-Cyclopropyl-1,2,4-triazol-3-ylamine is used as a building block for creating biologically active molecules due to its triazole core and cyclopropyl group, which contribute to a wide range of pharmacological activities and structural diversity.
Used in Drug Development:
In the pharmaceutical industry, 5-Cyclopropyl-1,2,4-triazol-3-ylamine is utilized for the development of new drugs targeting various medical conditions. Its unique structure allows for the modulation of biological activity, making it a valuable component in the creation of novel therapeutic agents.
Used in Materials Science:
5-Cyclopropyl-1,2,4-triazol-3-ylamine's structure also suggests potential applications in materials science, where it could be explored for its properties in different chemical research areas, contributing to the advancement of material technologies.
While the provided materials do not specify distinct applications in various industries beyond pharmaceutical research and drug development, the compound's versatility implies that it could be adapted for use in other sectors where novel chemical structures are of interest.

InChI:InChI=1/C5H8N4/c6-5-7-4(8-9-5)3-1-2-3/h3H,1-2H2,(H3,6,7,8,9)

Upstream product

• 2582-30-1 aminoguanidine bicarbonate 
• 1759-53-1 cyclopropanecarboxylic acid 

Downstream Products

• 1374306-18-9 2-cyclopropyl-3-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one 
• 1374306-33-8 C₁₅H₁₁Cl₃N₄O 
• 1374306-36-1 C₁₇H₁₄ClF₃N₄O 
• 1374306-11-2 2-cyclopropyl-3-[(2,3-dichlorophenyl)methyl]-5-(4-morpholinyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one 
• 67-56-1 methanol 
• 811821-08-6 2-cyclopropyl-6-(4-chloro-thiazol-5-yl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol 
• 82767-64-4 3-bromo-5-cyclopropyl-1H-[1,2,4]triazole 
• 1240468-89-6 2-cyclopropyl-6-(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol 
• 1239269-04-5 4'-[(2-cyclopropyl-5-oxo-7-propyl-4,5-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl]biphenyl-2-carbonitrile 

Relevant academic research and scientific papers

Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents

Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemistry effort. Structure-activity relationship studies followed by pharmacokinetics optimization resulted in the identification of 23 as an attractive lead with good oral bioavailability. Compound 23 was found to be efficacious (ED90 of 28.6 mg·kg-1) in the humanized P. falciparum mouse model of malaria (Pf/SCID model). Representative compounds displayed a moderate to fast killing profile that is comparable to that of chloroquine. This series demonstrates no cross-resistance against a panel of Pf strains with mutations to known antimalarial drugs, thereby suggesting a novel mechanism of action for this chemical class.