Technology Process of 2-[18F]fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
There total 9 articles about 2-[18F]fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[18F]-hydrofluoric acid; potassium carbonate; [2.2.2]cryptande;
In
dimethyl sulfoxide; acetonitrile;
at 140 ℃;
for 0.25h;
Irradiation;
DOI:10.1016/j.bmcl.2014.02.037
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / dichloromethane / 0.75 h / 20 °C / Reflux
2.1: aluminum (III) chloride / dichloromethane / 0.58 h / 20 °C / Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C
3.2: 5 h / 20 °C
4.1: potassium hydroxide / water; methanol / 2 h / Reflux
5.1: [18F]-hydrofluoric acid; potassium carbonate; [2.2.2]cryptande / acetonitrile; dimethyl sulfoxide / 0.25 h / 140 °C / Irradiation
With
[18F]-hydrofluoric acid; aluminum (III) chloride; n-butyllithium; potassium carbonate; [2.2.2]cryptande; potassium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
1.1: |Friedel-Crafts Alkylation / 2.1: |Friedel-Crafts Acylation / 3.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2014.02.037
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogenchloride / 2 h / 20 °C
2.1: aluminum (III) chloride / dichloromethane / 0.75 h / 20 °C / Reflux
3.1: aluminum (III) chloride / dichloromethane / 0.58 h / 20 °C / Reflux
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 20 °C
4.2: 5 h / 20 °C
5.1: potassium hydroxide / water; methanol / 2 h / Reflux
6.1: [18F]-hydrofluoric acid; potassium carbonate; [2.2.2]cryptande / acetonitrile; dimethyl sulfoxide / 0.25 h / 140 °C / Irradiation
With
[18F]-hydrofluoric acid; hydrogenchloride; aluminum (III) chloride; n-butyllithium; potassium carbonate; [2.2.2]cryptande; potassium hydroxide;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;
2.1: |Friedel-Crafts Alkylation / 3.1: |Friedel-Crafts Acylation / 4.2: |Wittig Olefination;
DOI:10.1016/j.bmcl.2014.02.037
