(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

Base Information

Chemical Name:(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide
CAS No.:1392506-18-1
Molecular Formula:C₃₄H₃₄ClFN₄O₃
Molecular Weight:601.12
Hs Code.:

Synonyms:(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

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Chemical Property of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

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Technology Process of (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

There total 4 articles about (R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1392506-10-3
(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide

: 459-32-5
(E)-4-fluorocinnamic acid

: 1392506-18-1
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

Guidance literature:: (E)-4-fluorocinnamic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.333333h; Reflux;

(R)-2-amino-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-4-methyl-pentanamide; In dichloromethane; for 72h;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 1198-40-9
4-amino-7-chloroquinoline

: 1392506-18-1
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

2.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

2.2: pH 12

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

4.2: pH 12

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

5.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.05.022

Reference yield:

: 1392506-08-9
(R)-2-amino-N-(7-chloroquinolin-4-yl)-4-phenylbutanamide

: 1392506-18-1
(R)-N-((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)-2-((E)-3-(4-fluoro-phenyl)acrylamido)-4-methylpentanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

1.2: 24 h / 0 - 20 °C

2.1: trifluoroacetic acid / 20 °C / Neat (no solvent)

2.2: pH 12

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / Reflux

3.2: 72 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2012.05.022