4-Amino-7-chloroquinoline

Base Information

Chemical Name:4-Amino-7-chloroquinoline
CAS No.:1198-40-9
Molecular Formula:C9H7ClN2
Molecular Weight:178.621
Hs Code.:29420000
European Community (EC) Number:601-638-8
NSC Number:13
UNII:2SJ6Y866TU
DSSTox Substance ID:DTXSID00152593
Nikkaji Number:J80.088K
Wikidata:Q72434959
Metabolomics Workbench ID:71596
ChEMBL ID:CHEMBL44789
Mol file:1198-40-9.mol

Synonyms:7-chloro-4-aminoquinoline

Suppliers and Price of 4-Amino-7-chloroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
7-Chloroquinolin-4-amine
250mg
$ 165.00

TRC
7-Chloroquinolin-4-amine
1g
$ 415.00

SynQuest Laboratories
4-Amino-7-chloroquinoline 95%
5 g
$ 756.00

SynQuest Laboratories
4-Amino-7-chloroquinoline 95%
1 g
$ 220.00

Sigma-Aldrich
4-Amino-7-chloroquinoline Aldrich
1g
$ 258.00

Matrix Scientific
7-Chloroquinolin-4-amine 95%+
10g
$ 1399.00

Matrix Scientific
7-Chloroquinolin-4-amine 95%+
5g
$ 1104.00

J&W Pharmlab
7-Chloro-quinolin-4-ylamine 97%
1g
$ 98.00

J&W Pharmlab
7-Chloro-quinolin-4-ylamine 97%
500mg
$ 88.00

J&W Pharmlab
7-Chloro-quinolin-4-ylamine 97%
250mg
$ 78.00

Total 60 raw suppliers

Chemical Property of 4-Amino-7-chloroquinoline

Chemical Property:

Vapor Pressure:1.42E-05mmHg at 25°C
Melting Point:150-152.5 °C
Refractive Index:1.712
Boiling Point:366.843 °C at 760 mmHg
PKA:7.49±0.50(Predicted)
Flash Point:175.66 °C
PSA：38.91000
Density:1.363 g/cm³
LogP:3.05160
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:178.0297759
Heavy Atom Count:12
Complexity:163

Purity/Quality:

97% ^*data from raw suppliers

7-Chloroquinolin-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 25-36
Safety Statements: 26-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=CN=C2C=C1Cl)N
Uses 7-Chloroquinolin-4-amine is an aminoquinoline that complexes ferriprotoporphyrin IX (Fe(III)PPIX) and inhibits its conversion to β-hematin (hemozoin).

Technology Process of 4-Amino-7-chloroquinoline

There total 20 articles about 4-Amino-7-chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1198-40-9
4-amino-7-chloroquinoline

Guidance literature:: With ammonium carbonate; phenol; at 110 - 165 ℃;
DOI:10.1021/acsmedchemlett.8b00053

Reference yield: 87.0%

: 23834-14-2
7-chloro-4-hydrazinoquinoline

: 1198-40-9
4-amino-7-chloroquinoline

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In methanol; at 20 ℃; for 0.25h;
DOI:10.1016/j.tetlet.2008.01.128

Reference yield: 86.0%

: 98591-57-2
7-chloro-4-iodoquinoline

: 1198-40-9
4-amino-7-chloroquinoline

Guidance literature:: With (2-hydroxyethyl)(methyl)amine; copper(l) iodide; formamide; at 80 ℃; for 2.5h; Reagent/catalyst; Sealed tube;
DOI:10.1039/c4nj00046c