N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

Base Information

Chemical Name:N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide
CAS No.:1255040-27-7
Molecular Formula:C₁₈H₂₅FN₄O₃S
Molecular Weight:396.486
Hs Code.:

Synonyms:N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

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Chemical Property of N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

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Technology Process of N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

There total 10 articles about N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1255040-27-7
N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tert.-butylnitrite; copper(l) iodide / acetonitrile / 0 - 65 °C

1.2: Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With copper(l) iodide; lithium aluminium tetrahydride; tert.-butylnitrite; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2017.08.020

Reference yield:

: 824426-35-9
2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionic acid

: 1349979-20-9,936940-66-8
C₈H₁₅N₃

: 1255040-27-7
N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.bmcl.2017.08.020

Reference yield:

: 75-97-8
3,3-dimethyl-butan-2-one

: 1255040-27-7
N-((3-tert-butyl-1H-pyrazol-5-yl)methyl)-2-(3-fluoro-4-(methylsulphonamido)phenyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C

2.1: hydrazine dihydrochloride; triethylamine / ethanol / 2 h / 20 °C

3.1: sodium hydroxide / water; methanol / 2 h / 20 °C

3.2: 20 °C

3.3: 1 h / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.2: 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 20 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With lithium aluminium tetrahydride; hydrazine dihydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.08.020