2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

Base Information

Chemical Name:2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid
CAS No.:1315336-67-4
Molecular Formula:C₂₃H₂₇N₅O₆
Molecular Weight:469.497
Hs Code.:

Synonyms:2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

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Chemical Property of 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

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Technology Process of 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

There total 7 articles about 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1315336-66-3
methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

: 1315336-67-4
2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

Guidance literature:: methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate; With lithium hydroxide monohydrate; In tetrahydrofuran; at 50 ℃;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-65-2
(4-(2-(2-(allyloxy)-4-aminophenyl)-2H-tetrazol-5-yl)phenyl)methanol

: 1315336-67-4
2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

3.1: lithium hydroxide monohydrate / tetrahydrofuran / 50 °C

3.2: pH 1

With methanol; lithium hydroxide monohydrate; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-57-2
methyl 4-(2-(2-(allyloxy)-4-nitrophenyl)-2H-tetrazol-5-yl)benzoate

: 1315336-67-4
2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol; water; iron; acetic acid / Sonication

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.01 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

5.1: lithium hydroxide monohydrate / tetrahydrofuran / 50 °C

5.2: pH 1

With methanol; lithium aluminium tetrahydride; lithium hydroxide monohydrate; ethanol; water; iron; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja204758c