methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

Base Information

Chemical Name:methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate
CAS No.:1315336-66-3
Molecular Formula:C₂₄H₂₉N₅O₆
Molecular Weight:483.524
Hs Code.:

Synonyms:methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

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Chemical Property of methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

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Technology Process of methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

There total 6 articles about methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 75-21-8,99932-75-9
oxirane

: 1339268-28-8
C₂₀H₂₁N₅O₄

: 1315336-66-3
methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

Guidance literature:: With methanol; In dichloromethane; at -78 - 70 ℃; for 15h; pressurized reaction vessel;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-65-2
(4-(2-(2-(allyloxy)-4-aminophenyl)-2H-tetrazol-5-yl)phenyl)methanol

: 1315336-66-3
methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

With methanol; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-57-2
methyl 4-(2-(2-(allyloxy)-4-nitrophenyl)-2H-tetrazol-5-yl)benzoate

: 1315336-66-3
methyl 2-((4-(2-(2-(allyloxy)-4-(bis(2-hydroxyethyl)amino)phenyl)-2H-tetrazol-5-yl)benzyl)oxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; water; iron; acetic acid / Sonication

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.01 h / 0 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: methanol / dichloromethane / 15 h / -78 - 70 °C / pressurized reaction vessel

With methanol; lithium aluminium tetrahydride; ethanol; water; iron; sodium hydride; acetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja204758c