8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Base Information

Chemical Name:8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole
CAS No.:1346262-81-4
Molecular Formula:C₂₅H₁₈ClN₃O
Molecular Weight:411.89
Hs Code.:

Synonyms:8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

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Chemical Property of 8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

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Technology Process of 8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

There total 6 articles about 8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1346262-70-1
C₁₇H₁₁ClN₂

: 13820-14-9
4-methylbenzonitrile oxide

: 1346262-81-4
8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: C₁₇H₁₁ClN₂; With triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; at 0 - 5 ℃; for 0.166667h; Inert atmosphere;

4-methylbenzonitrile oxide; In dichloromethane; at 0 - 20 ℃; for 0.633333h; regioselective reaction; Inert atmosphere;
DOI:10.1039/c1ob06072d

Reference yield:

: 3235-02-7,3717-15-5,3717-16-6,140461-26-3,140461-27-4
p-methylbenzaldehyde oxime

: 1346262-81-4
8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.1: triethylamine / dichloromethane / 0.03 h / 0 - 5 °C

3.1: triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

3.2: 0.63 h / 0 - 20 °C / Inert atmosphere

With N-chloro-succinimide; triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06072d

Reference yield:

: C₁₄H₉ClN₂

: 1346262-81-4
8-chloro-5-(3-(4-methylphenyl)isoxazol-5-ylmethyl)-5H-benzo(4,5)imidazo(2,1a) isoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 4 h / Reflux

2.1: triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride / dichloromethane / 0.17 h / 0 - 5 °C / Inert atmosphere

2.2: 0.63 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; 1,3-di-tert-butyl-1H-imidazol-3-ium chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c1ob06072d