2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Base Information

Chemical Name:2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile
CAS No.:1259926-38-9
Molecular Formula:C₃₉H₂₉F₃N₄O₃S
Molecular Weight:690.745
Hs Code.:

2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Synonyms:2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

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Chemical Property of 2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

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Technology Process of 2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

There total 13 articles about 2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

: 1259926-37-8
5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)-methylamino]-phenyl}-vinyl)-thiophene-2-carbaldehyde

: 436097-14-2
[3-cyano-4-methyl-5-phenyl-5-(trifluoromethyl)-2(5H)-furanylidene]propanedinitrile

: 1259926-38-9
2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: In tetrahydrofuran; ethanol; at 20 - 50 ℃; for 21h;

Reference yield:

: 1267605-77-5
2-{[3-benzyloxy-4-(2-thiophene-2-ylvinyl)-phenyl]-methylamino}ethanol

: 1259926-38-9
2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: -78 - 0 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

4.1: tetrahydrofuran; ethanol / 48 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; In tetrahydrofuran; ethanol; hexane; N,N-dimethyl-formamide; 4.1: Knoevenagel condensation;
DOI:10.1002/pola.24410

Reference yield:

: 33905-38-3
3-(benzyloxy)-N-methylaniline

: 1259926-38-9
2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydrogencarbonate / acetonitrile / 4 h / Inert atmosphere; Reflux

2.1: sodium tetrahydroborate; lithium bromide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

3.1: pyridine / toluene / 4 h / 20 - 85 °C / Inert atmosphere

4.1: trichlorophosphate / 0 - 20 °C / Inert atmosphere

5.1: phenyllithium / tetrahydrofuran; dibutyl ether / 1.5 h / 0 °C / Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 1 h / 40 °C

7.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

8.2: -78 - 0 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

10.1: tetrahydrofuran; ethanol / 48 h / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; phenyllithium; lithium bromide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; hexane; dibutyl ether; N,N-dimethyl-formamide; toluene; acetonitrile; 5.1: Wittig reaction / 10.1: Knoevenagel condensation;
DOI:10.1002/pola.24410