436097-14-2

Usage

Uses

Used in Organic Synthesis:
2-dicyanoMethylene-3-cyano-4-Methyl-5-phenyl-5-trifluoroMethyl-2,5-dihydrofuran is used as a reagent in organic synthesis for its high reactivity and ability to form a variety of organic compounds. Its presence of cyanide and trifluoromethyl groups allows for the creation of diverse chemical products through different synthetic pathways.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-dicyanoMethylene-3-cyano-4-Methyl-5-phenyl-5-trifluoroMethyl-2,5-dihydrofuran is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Development:
Similarly, in agrochemicals, 2-dicyanoMethylene-3-cyano-4-Methyl-5-phenyl-5-trifluoroMethyl-2,5-dihydrofuran is utilized as a key intermediate in the synthesis of pesticides and other agrochemicals, leveraging its reactive functional groups to create effective compounds for agricultural use.
Used in Fine Chemicals Production:
2-dicyanoMethylene-3-cyano-4-Methyl-5-phenyl-5trifluoroMethyl-2,5-dihydrofuran also finds application in the production of fine chemicals, where its specific reactivity and structural features are harnessed to create specialty chemicals for various industries, including fragrances, dyes, and other high-value chemical products.
Used in Chemical Research and Development:
2-dicyanoMethylene-3-cyano-4-Methyl-5-phenyl-5-trifluoroMethyl-2,5-dihydrofuran is a valuable tool in chemical research and development, where its unique properties are explored for new reactions and applications, potentially leading to breakthroughs in material science and other related fields.

Upstream product

• 130865-83-7 Ethyl α-hydroxy-α-(trifluoromethyl)phenylacetate 
• 109-77-3 malononitrile 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 436097-07-3 4,4,4-trifluoro-3-hydroxy-3-phenyl-2-butanone 

Downstream Products

• 1042150-17-3 C₄₇H₄₀F₃N₅O₃S 
• 1260100-70-6 YLD₁₂₄ 
• 958001-69-9 C₄₄H₄₉F₃N₄O₂Si 
• 1297378-64-3 C₄₃H₄₇F₃N₄O₂Si 
• 1297378-62-1 C₄₅H₄₉F₃N₄O₂Si 
• 1259926-43-6 C₃₂H₂₃F₃N₄O₂S 
• 1259926-38-9 2-(4-{2-[5-(2-{2-benzyloxy-4-[(2-hydroxyethyl)methylamino]phenyl}vinyl)thiophene-2-yl]vinyl}-3-cyano-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)malononitrile 
• 1354221-98-9 C₈₂H₆₁F₁₃N₄O₁₀ 

Relevant academic research and scientific papers

Systematic study of the structure-property relationship of a series of ferrocenyl nonlinear optical chromophores

A series of novel nonlinear optical (NLO) chromophores 1-4 incorporating the ferrocenyl (Fc) group as an electron donor and 2-dicyanomethylene-3-cyano-4- methyl-2,5-dihydrofuran (TCF) derivatives as electron acceptors are presented. The use of a constant Fc donor and varied acceptors and bridges makes it possible to systematically determine the contribution of the conjugated bridge and the acceptor strength to chromophore nonlinear optical activity. The X-ray crystal structures of all four chromophores allow for the systematic investigation of the structure-property relationship for this class of molecules. For example, the crystal structures reveal that both cyclopentadienyl groups in the ferrocenyl donor contribute to the electron donating ability. The first-order hyperpolarizabilities β of these chromophores, measured by hyper-Rayleigh scattering (HRS) relative to p-nitroaniline are reported. These β values are compared to those calculated by density functional theory (DFT). The excellent agreement between the theoretical and experimental β values demonstrates that a linear relation exists between the hyperpolarizability and the bond length alternation. An electrooptic coefficient, r33, of ～25 pm/V at 1300 nm, for compound 4, incorporated into a polymer matrix, is competitive with organic chromophores. Moreover, this r33 is more than 30 times larger than the previously reported value for an organometallic chromophore in a poled polymer matrix. This work not only underscores the potential for Fc donor moieties, which have been underutilized, but also demonstrates that experimental characterization and theoretical simulations are now congruent, viable methods for assessing potential performance of NLO materials.

Microwave synthesis with D - π - A structure of second-order non-linear optical chromophore method

The invention belongs to a synthesis method of an organic second-order nonlinear optical chromophore with a cyclic polyene structure compound as an electron bridge and especially relates to a second-order nonlinear optical chromophore which is synthesized by microwave heating, contains a high-performance electron donor (D) of an aldehyde group, a cyclic polyene structured electron bridge (pi) and a tricyano-dihydro furan (TCF) or trifluoro-substituted tricyano-dihydro furan (CF3-TCF) electron acceptor (A) and has a D-pi-A structure. The second-order nonlinear optical chromophore has a structure as shown in the specification. By a microwave heating method, the electron donor and the compound with the cyclic polyene structure undergo a chemical reaction in the presence of anhydrous ethanol and sodium ethoxide. Heat energy loss is reduced, reaction molecular collision probability is enhanced, reaction time is greatly shortened, reaction rate is increased, and reaction yield is raised.

With D - π - A structure of the organic second-order non-linear optical chromophore and synthetic method and use

The invention relates to the field of organic second-order nonlinear optical materials and especially relates to an organic second-order nonlinear optical chromophore which has a D-pi-A structure and utilizes julolidine or its derivative as an electron donor, a thiophene ring or a cyclic polyene structure as a conjugate electron bridge and tricyano-dihydro furan or trifluoro-substituted tricyano-dihydro furan as an electron acceptor, and its synthesis method and use. Through combination of the used electron donor, conjugate pi electron bridge and electron acceptor, the organic second-order nonlinear optical chromophore can improve an intramolecular electron transfer capability and improve intermolecular steric hindrance. The organic second-order nonlinear optical chromophore can effectively improve a chromophore molecule first-order hyperpolarization rate (beta) and can effectively reduce intermolecular interaction. The organic second-order nonlinear optical chromophore adopted with amorphous polycarbonate can be used for preparation of a polarized polymer film. The polarized polymer film can be used as a material in the optical signal modulation field. The organic second-order nonlinear optical chromophore has a structure shown in the following description.

Structure-function relationship exploration for enhanced thermal stability and electro-optic activity in monolithic organic NLO chromophores

We have developed a series of novel monolithic materials based on molecules previously explored as dopants in guest-host systems to study intrinsic structure-function relationships in organic electro-optic (EO) materials. In a library of EO molecules with varied bridge segments, molecular modification of the donor with bis(tert-butyldiphenylsilyl) groups led to improvement in formation of amorphous films and led to enhanced poling efficiency. Further modification to include a carbazole site-isolation group on the bridge effectively reduced intermolecular dipole-dipole interactions, led to a material with poling efficiency of approximately 3 (nm V-1)2, and an increased glass transition temperature to 20-40 °C higher than similar reported monolithic materials. This level of thermal stability is comparable to common guest/host systems, which incorporated poly(methyl methacrylate) (PMMA) as the host. Our research showed that π-bridge length and type impacted first molecular hyperpolarizability β of a chromophore, which is accordingly reflected in the EO response. These findings further promote the utility of monolithic materials for their increased EO behavior and improved thermal stability, making this material system a competitor of guest-host systems in commercial applications.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX

Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysiologically related to GPR35 in a subject. The compounds having a formula (I), (II) or (III):