Technology Process of (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenal
There total 6 articles about (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) potassium tert-butoxide / 1.) 0 deg C, 20 min, 2.) 25 deg C
2: 1.45 g / 1N HCl / tetrahydrofuran; H2O / 3 h / Ambient temperature
3: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) dichloromethane, -60 deg C, 30 min, 2.) -25 deg C, 15 min
4: 1.) butyllithium,diisopropylamine, 2.) oxalic acid dihydrate, 3.) water / 1.) THF, -78 deg C, 1.25 h, 25 deg C, 2 h, 2.) reflux, 1 h, 3.) reflux, 1.5 h
With
hydrogenchloride; n-butyllithium; oxalyl dichloride; potassium tert-butylate; water; oxalic acid; dimethyl sulfoxide; triethylamine; diisopropylamine;
In
tetrahydrofuran; water;
DOI:10.1021/ja00353a027
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.45 g / 1N HCl / tetrahydrofuran; H2O / 3 h / Ambient temperature
2: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) dichloromethane, -60 deg C, 30 min, 2.) -25 deg C, 15 min
3: 1.) butyllithium,diisopropylamine, 2.) oxalic acid dihydrate, 3.) water / 1.) THF, -78 deg C, 1.25 h, 25 deg C, 2 h, 2.) reflux, 1 h, 3.) reflux, 1.5 h
With
hydrogenchloride; n-butyllithium; oxalyl dichloride; water; oxalic acid; dimethyl sulfoxide; triethylamine; diisopropylamine;
In
tetrahydrofuran; water;
DOI:10.1021/ja00353a027
- Guidance literature:
-
With
n-butyllithium; water; oxalic acid; diisopropylamine;
Yield given. Multistep reaction;
1.) THF, -78 deg C, 1.25 h, 25 deg C, 2 h, 2.) reflux, 1 h, 3.) reflux, 1.5 h;
DOI:10.1021/ja00353a027
