p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

Base Information

Chemical Name:p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate
CAS No.:95910-00-2
Molecular Formula:C₃₀H₃₀N₄O₈S₂
Molecular Weight:638.722
Hs Code.:

p-nitrobenzyl (RS)-7-<N-(tert-butoxycarbonyl)-3-benzothienylglycylamido>-3-methyl-3-cephem-4-carboxylate

Synonyms:p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

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Chemical Property of p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

Chemical Property:

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Technology Process of p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

There total 4 articles about p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 29124-83-2
p-nitrobenzyl ester of 7-aminodeacetoxycephalosporanic acid

: 95834-98-3
(RS)-N-(tert-butoxycarbonyl)-3-benzothienylglycine

: 95910-00-2
p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In tetrahydrofuran; acetonitrile; at 25 ℃; for 5.5h;
DOI:10.1021/jm00150a024

Reference yield:

: 95835-19-1
<2-(hydroxyimino)-3-benzothienyl>acetic acid

: 95910-00-2
p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.35 g / H₂ / 5 percent Pd/C / methanol / 3 h / 24 °C / 3102.9 Torr

2: 92 percent / Et₃N / H₂O; tetrahydrofuran

3: 95 percent / EEDQ / tetrahydrofuran; acetonitrile / 5.5 h / 25 °C

With hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1021/jm00150a024

Reference yield:

: 34619-03-9
tert-butyldicarbonate

: 95910-00-2
p-nitrobenzyl (RS)-7--3-methyl-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Et₃N / H₂O; tetrahydrofuran

2: 95 percent / EEDQ / tetrahydrofuran; acetonitrile / 5.5 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm00150a024