2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

Base Information

Chemical Name:2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione
CAS No.:1352754-66-5
Molecular Formula:C₂₃H₁₉NO₅S
Molecular Weight:421.474
Hs Code.:

Synonyms:2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

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Chemical Property of 2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

There total 8 articles about 2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 54974-07-1
phthalimidesulfenyl chloride

: 1352754-65-4
5-(benzyloxy)-2-methoxy-4-methylphenol

: 1352754-66-5
2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

Guidance literature:: With 2,6-di-tert-butyl-pyridine; In chloroform; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201101146

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1352754-66-5
2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 8 steps

1: potassium hydroxide; hydrazine / ethylene glycol / 19 h / 150 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 20 °C

3: aluminum (III) chloride / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

5: sodium hydride / tetrahydrofuran / 0 - 20 °C

6: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

7: sodium hydroxide / methanol / 24 h / 20 °C

8: 2,6-di-tert-butyl-pyridine / chloroform / 0 - 20 °C / Inert atmosphere

With aluminum (III) chloride; 2,6-di-tert-butyl-pyridine; sodium hydride; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; sodium hydroxide; hydrazine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; ethylene glycol; 1: Wolf-Kishner reduction / 6: Baeyer-Villiger oxidation;
DOI:10.1002/chem.201101146

Reference yield:

: 1352754-63-2
1-(5-(benzyloxy)-2-methoxy-4-methylphenyl)ethanone

: 1352754-66-5
2-(2-(benzyloxy)-6-hydroxy-5-methoxy-3-methylphenylthio)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

2: sodium hydroxide / methanol / 24 h / 20 °C

3: 2,6-di-tert-butyl-pyridine / chloroform / 0 - 20 °C / Inert atmosphere

With 2,6-di-tert-butyl-pyridine; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In methanol; dichloromethane; chloroform; 1: Baeyer-Villiger oxidation;
DOI:10.1002/chem.201101146