3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one

Base Information

• Chemical Name: 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one
• CAS No.: 104586-83-6
• Molecular Formula: C₂₁H₁₆F₄N₂O
• Molecular Weight: 388.364
• Mol file: 104586-83-6.mol

Synonyms:3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one

Chemical Property of 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one

There total 5 articles about 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

o-trifluoromethylbenzyl bromide (395-44-8) + 9-amino-3,4-dihydro-6-fluoroacridin-1(2H)-one (104586-55-2) → 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one (104586-83-6)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; for 4h;

DOI:10.1021/jm00128a024

Reference yield:

2-(trifluoromethyl)benzyl chloride (21742-00-7) + benzyl chloride (100-44-7) + 9-amino-3,4-dihydro-6-fluoroacridin-1(2H)-one (104586-55-2) → 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one (104586-83-6)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

1,3-cylohexanedione (504-02-9) → 3,4-Dihydro-6-fluoro-9-(2-trifluoromethylbenzylamino)-acridin-1(2H)-one (104586-83-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / p-toluenesulfonic acid monohydrate / toluene / 2 h / Heating

2: 93 percent / K₂CO₃ / CuCl / tetrahydrofuran / 5 h / Heating

3: 80 percent / NaOH / 4N>4> / CH₂Cl₂; H₂O / 4 h

With sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; tetra(n-butyl)ammonium hydrogensulfate; copper(l) chloride; In tetrahydrofuran; dichloromethane; water; toluene;

DOI:10.1021/jm00128a024

upstream raw materials:

o-trifluoromethylbenzyl bromide

9-amino-3,4-dihydro-6-fluoroacridin-1(2H)-one

1,3-cylohexanedione

2-amino-4-fluorobenzonitrile

Downstream raw materials:

6-fluoro-1,2,3,4-tetrahydro-9-(2-trifluoromethylbenzylamino)acridin-1-ol