tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate
CAS No.:1622205-28-0
Molecular Formula:C₃₃H₃₇N₅O₆
Molecular Weight:599.687
Hs Code.:

Synonyms:tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

There total 10 articles about tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.5%

: 149353-75-3
4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

: 1622205-27-9
5-((2-aminopyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide

: 1622205-28-0
tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid; With 1,2,3-Benzotriazole; thionyl chloride; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;

5-((2-aminopyridin-4-yl)oxy)-6-methoxy-N-methyl-1H-indole-1-carboxamide; With dmap; triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

Reference yield:

: 1622205-26-8
4-((6-methoxy-1H-indol-5-yl)oxy)pyridin-2-amine

: 1622205-28-0
tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

2.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

2.2: 5 h / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1622205-28-0
tert-butyl 4-(4-((4-((6-methoxy-1-(methylcarbamoyl)-1H-indol-5-yl)oxy)pyridin-2-yl)carbamoyl)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / acetone / 18.17 h / 25 °C / Inert atmosphere

2.1: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

2.2: 5 h / 0 - 20 °C

With 1,2,3-Benzotriazole; thionyl chloride; sodium hydroxide; In dichloromethane; acetone;