N-BOC-4-(4-CARBOXYPHENYL) PIPERIDINE

Base Information

• Chemical Name: N-BOC-4-(4-CARBOXYPHENYL) PIPERIDINE
• CAS No.: 149353-75-3
• Molecular Formula: C17H23NO4
• Molecular Weight: 305.374
• Hs Code.: 2933399090
• Mol file: 149353-75-3.mol

Synonyms:4-(4-Carboxyphenyl)piperidine-1-carboxylicacid tert-butyl ester;4-[1-(tert-Butoxycarbonyl)piperidin-4-yl]benzoic acid;4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester;

Chemical Property of N-BOC-4-(4-CARBOXYPHENYL) PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 447.971 °C at 760 mmHg
• PKA: 4.31±0.10(Predicted)
• Flash Point: 224.725 °C
• PSA: 66.84000
• Density: 1.168 g/cm³
• LogP: 3.43720
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-4-(4-carboxyphenyl)piperidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-4-(4-CARBOXYPHENYL) PIPERIDINE

There total 18 articles about N-BOC-4-(4-CARBOXYPHENYL) PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(1-tert-butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)benzoic acid (222987-62-4) → 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid (149353-75-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 60 ℃; for 8h; under 3750.38 Torr; Autoclave;

Reference yield: 94.0%

C17H23NO5 → 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid (149353-75-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; acetic acid; In methanol; at 80 ℃; for 8h; under 3750.38 Torr; Autoclave;

Reference yield: 91.0%

4-(4-carboxyphenyl)-piperidine-hydrochloride (149353-84-4) + di-tert-butyl dicarbonate (24424-99-5) → 4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid (149353-75-3)

Guidance literature:

With sodium hydroxide; In acetone; at 25 ℃; for 18.1667h; Inert atmosphere;

upstream raw materials:

4-(1-tert-butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)benzoic acid

4-Bromobenzoic acid

tert-butyl 4-iodopiperidine-1-carboxylate

4-(4-carboxyphenyl)-piperidine-hydrochloride

Downstream raw materials:

4-(4-chlorocarbonyl-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

N-(2-t-butoxycarbonylaminophenyl)-4-(1-t-butoxycarbonylpiperidin-4-yl)benzamide

1-[4-(1-tert-butoxycarbonylpiperidin-4-yl)benzoyl]-4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazine

tert-butyl 4-(4-(methoxy(methyl)carbamoyl)phenyl)piperidine-1-carboxylate

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